Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine composition for preventing and treating dyslipidemia and preparation method of traditional Chinese medicine composition for preventing and treating dyslipidemia

A lipid metabolism disorder and composition technology, applied in the field of traditional Chinese medicine extract composition, can solve the problems that the active ingredients cannot be properly purified, affect the stability of the clinical efficacy of the product, and the compliance of patients is not ideal, and achieve The effective ingredients are clear, safe, no obvious toxic and side effects, and the product quality is controllable

Inactive Publication Date: 2016-03-02
GUANGDONG PHARMA UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, although many compound Chinese medicines in China have good blood lipid regulation function and clinical curative effect, there are still many shortcomings because they are Chinese medicine compound preparations: (1) The composition is relatively complicated, and its active ingredients are not clear and difficult to quantify. Ultimately, it will affect the stability of the clinical efficacy of the product. (2) Relatively simple preparation process, the active ingredients in the prescription cannot be properly purified, there are many impurities, the dosage is large, and the compliance of patients is not ideal. (3) Due to the large amount of prescription extracts, the scope of application is subject to various restrictions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine composition for preventing and treating dyslipidemia and preparation method of traditional Chinese medicine composition for preventing and treating dyslipidemia
  • Traditional Chinese medicine composition for preventing and treating dyslipidemia and preparation method of traditional Chinese medicine composition for preventing and treating dyslipidemia
  • Traditional Chinese medicine composition for preventing and treating dyslipidemia and preparation method of traditional Chinese medicine composition for preventing and treating dyslipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1FSN

[0038] One, the preparation of bergamot total phenolic extract

[0039] (1) Bergamot total phenolic extract 1

[0040] Weigh 10 kg of bergamot medicinal materials, pulverize them, and extract 8 times and 7 times the amount of medicinal materials with 70% ethanol by reflux, respectively, for 2 hours each time. The combined extracts are filtered with a 200-mesh filter cloth, and the filtrates are combined. Recover the ethanol and make the concentration of the ethanol extraction part be 1ml of concentrated solution (10L) equivalent to 1g of crude drug; absorb on a macroporous resin column, and the macroporous resin is preferably polyamide type B-8. Add 1kg of resin and 1.3L of concentrated solution to the macroporous resin column for adsorption, wash with water until the eluent is nearly colorless, then use 6L of 80% ethanol to elute at a flow rate of 9ml / min, elute until the effluent is colorless, and combine for elution Liquid, etha...

Embodiment 2

[0097] The effect of embodiment 2 FSN on the key enzyme gene expression and activity of blood lipid metabolism

[0098] 1.1 Effects on gene expression and activity of hepatic lipase (HL) enzyme and cholesterol 7-α-hydroxylase (CYP7A1) in hepatocytes

[0099] Cultivate L-O2 human normal hepatocytes as usual, add various concentrations of FSN, FS, FN and FTZ after the cells are fused, continue to culture for a certain period of time, collect the cells to make cell homogenate, and use the HL detection kit, The enzyme activities of HL and CYP7A1 were detected by colorimetry, the effects of the above-mentioned different concentrations of FSN on the enzyme activities of HL and CYP7A1 were studied, and the enzyme activities of HL and CYP7A1 in hepatocytes under the action of different concentrations of FSN were compared. In addition, Trigol reagent was used to extract total RNA in hepatocytes, and the expression of CYP7A1 and HL enzyme genes in hepatocytes was determined by RT-PCR, a...

Embodiment 3

[0115] The effect of embodiment 3FSN on experimental rat hyperlipidemia

[0116] Experimental animals: SD rats, SPF grade, male, body weight 200±20g.

[0117]Experimental method: After one week of adaptive feeding, the rats were randomly divided into normal control group and model-making group according to body weight, of which 10 in the normal control group were fed with basic feed; 110 in the model-making group were fed with high-fat feed for 2 weeks. Orbital blood was taken to measure blood lipids, and those with significantly higher blood lipids were selected as rats with successful hyperlipidemia modeling.

[0118] Those whose blood TC value was higher than 2.5mmol / L were included in the experiment, and hyperlipidemia rats were divided into hyperlipidemia model group, each extract group and positive drug simvastatin (20mg / kg body weight·d) group according to the blood lipid level. Group 10. The normal control group and the hyperlipidemia model group were given equal vol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Relative densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating dyslipidemia. The traditional Chinese medicine composition for preventing and treating dyslipidemia comprises fructus citrus sarcodactylis extract, total panax notoginseng saponin extract and total fructus ligustri lucidi organic acid extract. The invention further discloses a preparation method of the traditional Chinese medicine composition. The preparation method includes subjecting fructus citrus sarcodactylis, panax notoginseng and fructus ligustri lucidi to C1-3 alcohol extraction respectively prior to purification so as to obtain total fructus citrus sarcodactylis phenol extract, the total panax notoginseng saponin extract and total tritepenoidic acid alkaloid extract, and mixing the total fructus citrus sarcodactylis phenol extract, the total panax notoginseng saponin extract and the total tritepenoidic acid alkaloid extract so as to obtain a plant extract composition for preventing and treating dyslipidemia diseases. The traditional Chinese medicine composition for preventing and treating dyslipidemia and the preparation method have the advantages that a great quantity of inactive chemical ingredients in an original compound traditional Chinese medicine are removed while active ingredient content is increased greatly, influences of the inactive ingredients on production processing, preparation quality and safety are reduced while the active ingredients are definite, stability in preparation technology and controllability in product quality are achieved, and industrial production is benefited; the traditional Chinese medicine composition is much higher in dyslipidemia disease resisting effect and is more stable and better in effect when being used for preventing and treating the dyslipidemia diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract composition, in particular to a traditional Chinese medicine composition for preventing and treating lipid metabolism disorder and a preparation method thereof. Background technique [0002] With the improvement of living standards, the dietary structure of Chinese residents is mainly high in sugar, high fat and high protein, which leads to major metabolic diseases related to glucose and lipid metabolism disorders, such as type 2 diabetes, obesity, hyperlipidemia and fatty liver. A significant increase occurred. According to the latest epidemiological survey, there are currently more than 300 million patients with their own lipid metabolism disorders in my country. Among the many lipid metabolism disorders in China, hypertriglyceridemia and non-alcoholic fatty liver are the two most common types . The prevalence of hypertriglyceridemia in my country exceeds 11.9%, and the prevalence of no...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/752A61P3/06A61P3/00A61P3/10A61P1/16A23L33/00
Inventor 郭姣何伟贝伟剑荣向路
Owner GUANGDONG PHARMA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com