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Medicine composition for treating gouty arthritis and application thereof

A technology of gouty arthritis and composition, which is applied in the field of pharmaceutical composition for the treatment of gouty arthritis, which can solve the problems of affecting the life and work of patients, huge gastrointestinal tract irritation, and patients' intolerance, so as to relieve local swelling Effects on pain, avoidance of gastrointestinal reactions, and inhibition of uric acid production

Inactive Publication Date: 2016-03-02
钟柏根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, non-steroidal anti-inflammatory painkillers such as colchicine or indomethacin are mainly used in the treatment of gouty arthritis, but the side effects are relatively large, especially the stimulation of the gastrointestinal tract, which is often difficult for patients to tolerate and seriously affects patients. life and work

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The preparation of embodiment 1 Chinese medicine extract

[0013] Weigh 0.15kg of Atractylodes atractylodis, 0.15kg of banana peel, 0.30kg of Pueraria lobata, 0.30kg of scorpion, 0.07kg of silkworm, 0.15kg of Shanzi mushroom, 0.12kg of mulberry branch, and 0.15kg of Sophora japonica, combine them, add water to decoct twice, and the first The amount of water added for the first time is 12 times the total weight of the medicinal materials, and the amount of water is 10 times the total weight of the medicinal materials, and the amount of water is 10 times the total weight of the medicinal materials. Concentrate under reduced pressure to 70°C when the relative density is 1.15, add ethanol to make the volume alcohol content reach 75%, stir, stand overnight, filter, and the filtrate is concentrated under reduced pressure at 0.08MPa and 65°C to a relative density of 1.35 The extract is put in a stainless steel pan, vacuum-dried (below 60° C.) into a dry paste, pulverized, and ...

Embodiment 2

[0014] Example 2 Effect Test of Chinese Medicine Extract on Gouty Arthritis Model Mice

[0015] The pharmaceutical composition of the present invention is an ancestral prescription for the treatment of gout, and has shown a good therapeutic effect in clinical use. In this experiment, through the influence of medicine on acute gouty arthritis rat model UA, IL-6, IL-8, further Discuss the mechanism of its treatment.

[0016] Sixty male Wistar rats, weighing 180g-220g, were randomly divided into normal group, model group, low-dose and high-dose Chinese medicine groups, 8 rats in each group. After the test started, the Chinese medicine low and high dose groups were given Chinese medicine extract (prepared according to the prescription process of Example 1) 600, 300 mg / kg / time by intragastric administration respectively, and the normal group and the model group were given equal volumes of purified water by intragastric administration respectively. , 2 times a day, given the test s...

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Abstract

The invention discloses a medicine composition for treating gouty arthritis and application thereof. The medicine composition is prepared from, by weight, 11-19 parts of rhizoma atractylodis, 11-19 parts of banana peels, 26-34 parts of kudzu vine roots, 26-34 parts of yam rhizomes, 5-9 parts of stiff silkworms, 11-19 parts of Indian iphigenia bulb, 9-15 parts of mulberry twigs and 12-18 parts of pagodatree pod. The medicine composition has the effects of inhibiting uricopoiesis, promoting uric acid excretion and relieving local swelling and pain and also avoids the toxic and side effects, such as gastrointestinal reaction, kidney function affection and decrease of white blood cells, produced in western medicine treatment.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating gouty arthritis and its application. Background technique [0002] Gouty arthritis is a clinical syndrome caused by guanine metabolism disorder and decreased uric acid excretion, which leads to continuous increase of uric acid content, causing urate deposition in joints, inflammatory response to external stimuli, and tissue damage. The initial clinical symptom of gout is acute gouty arthritis, which is characterized by sudden onset of acute single or multiple joint pain at night. Accumulation of sodium urate crystals in joints is the cause of acute gouty arthritis. Due to some reasons, such as guanine metabolism disorder and decreased excretion of uric acid, the content of uric acid in the blood is relatively high. In some joints and periarticular tissues, due to the lack of blood vessels in this part, it is easy to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P19/06A61P19/02A61K35/64
CPCA61K36/8945A61K36/898A61K35/63A61K36/284A61K36/488A61K36/489A61K36/605A61K36/88A61K2300/00
Inventor 钟柏根
Owner 钟柏根
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