Unlock instant, AI-driven research and patent intelligence for your innovation.

Chiral polyoxometalate and its preparation method and application

An oxoacid and chiral technology, which is applied in the field of chiral polyoxometalate and its preparation, can solve the problems of lack of targeting, clinical application and poor recognition ability of POMs, and achieve the elimination of cytotoxicity, Good suppression effect and high sensitivity effect

Active Publication Date: 2018-03-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problems in the prior art that POMs lack targeting, have poor recognition ability in complex biological environment systems, and cannot realize clinical application, and provide a chiral polyoxometalate and its Preparation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chiral polyoxometalate and its preparation method and application
  • Chiral polyoxometalate and its preparation method and application
  • Chiral polyoxometalate and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The preparation method of chiral polyoxometalate of the present invention comprises the following steps:

[0040] (1) Dissolve the aminated Anderson-type POM and succinic anhydride in anhydrous acetonitrile according to the amount of substance 1: (2-10), stir and react at room temperature for more than 24h, generally stir at 200-400r / min for 24-48h, remove Precipitate, and the filtrate is placed in ether atmosphere for crystallization to obtain crystals, which are carboxylated Anderson-type POM;

[0041] (2) Dissolve carboxylated Anderson-type POM, NHS and DCC in anhydrous DMF according to the amount of substances 1:1:1, stir at room temperature for more than 24h, generally stir at 200-400r / min for 24-48h, and remove the precipitate. The filtrate was crystallized in an ether atmosphere to obtain crystals, which were carboxyl-activated Anderson-type POM;

[0042] (3) Dissolve carboxyl-activated Anderson-type POM and chiral amino acid in anhydrous DMF according to the ra...

Embodiment 1

[0052] Chiral polyoxometalate, structural formula as shown in formula (I), in formula (I), R is

[0053]

[0054] The preparation method of above-mentioned inhibitor, comprises the following steps:

[0055] (1) Dissolve aminated Anderson-type POM and succinic anhydride in anhydrous acetonitrile according to the amount of substances 1:2, stir and react at room temperature for 24 hours, remove the precipitate, and crystallize the filtrate in an ether atmosphere to obtain crystals, which are carboxyl groups Anderson type POM;

[0056] (2) Carboxylated Anderson-type POM, NHS and DCC were dissolved in anhydrous DMF according to the amount of substances 1:1:1, stirred and reacted at room temperature for 24 hours, and the precipitate was removed. The filtrate was crystallized in an ether atmosphere to obtain crystals, namely Activate Anderson-type POM for carboxyl groups;

[0057] (3) Carboxyl-activated Anderson-type POM and L-His were dissolved in anhydrous DMF at a ratio of 1:...

Embodiment 2

[0059] Chiral polyoxometalate, structural formula is shown in formula (I), and R is

[0060]

[0061] The preparation method of above-mentioned inhibitor, comprises the following steps:

[0062] (1) Dissolve the aminated Anderson-type POM and succinic anhydride in anhydrous acetonitrile according to the amount of substances 1:4, stir and react at room temperature for 24 hours, remove the precipitate, and crystallize the filtrate in an ether atmosphere to obtain crystals, which are carboxyl groups Anderson type POM;

[0063] (2) Carboxylated Anderson-type POM, NHS and DCC were dissolved in anhydrous DMF according to the amount of substances 1:1:1, stirred and reacted at room temperature for 24 hours, and the precipitate was removed. The filtrate was crystallized in an ether atmosphere to obtain crystals, namely Activate Anderson-type POM for carboxyl groups;

[0064] (3) Dissolve carboxyl-activated Anderson-type POM and D-His in anhydrous DMF at a ratio of 1:5, stir and re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a chiral polyoxometalate, a preparation method and applications thereof, and belongs to the technical field of protein inhibitors. In the prior art, POMs lacks of targeting property, has poor recognition capacity in a complex biological environment system, and incapably achieves clinical applications. A purpose of the present invention is to solves the technical problems in the prior art. According to the present invention, the chiral polyoxometalate has a structural formula represented by a formula (I), wherein R is the residue obtained by removing an amino hydrogen from L-His, D-His, L-Asp, D-Asp, L-Leu, D-Leu, L-Phe or D-Phe; and the chiral polyoxometalate can be used as the A[beta] inhibitor, can penetrate the blood-brain barrier, provides high affinity and high selectivity for A[beta] in a physiological environment, and provides the rich tool for AD treatment. The formula (I) is defined in the specification.

Description

technical field [0001] The invention belongs to the technical field of protein inhibitors, and in particular relates to a chiral polyoxometalate and its preparation method and application. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. The clinical manifestations are the acquired high-level functional impairment of the cerebral cortex, that is, dementia, which mainly includes varying degrees of memory loss, impairment of sensory ability, judgment, thinking ability, motor ability, etc., as well as emotional response disorders and personality changes. At present, AD has become the fourth largest killer of human health after cardiovascular disease, cancer and cerebral apoplexy in modern society. According to the statistics of the World Health Organization, at the beginning of this century, the cost of caring for AD patients in the world accounted for 11.2% of the total expenditure of the p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D233/64C07C233/47A61P25/28
CPCC07C233/47C07D233/64
Inventor 曲晓刚高楠
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI