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A method for improving the yield of medical sodium hyaluronate refined product
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A technology of sodium hyaluronate and refined products, which is applied in the field of improving the yield of medical sodium hyaluronate refined products, which can solve the problems of difficult filtration of ethanol, thick sediment, and reduced yield, so as to improve the yield and quality , short drying time and improved yield
Active Publication Date: 2017-12-29
ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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The obtained sediment is viscous, and it is easy to form a thin film on the surface when it is filtered through the filter plate of the "filter washing and drying machine".
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Embodiment 1
[0018] Comparative process: Add 2 times the amount of 95% ethanol to 100 L of the filtered complex solution, stir, filter, wash, and vacuum dry to obtain a medical sodium hyaluronate refined product.
[0019] The present invention: 2 times of 95% ethanol is added to the complex solution after 100L filtration, after being stirred and static, 100L of the supernatant is drained, and 100L of 95% ethanol is added, stirred, static, filtered, washed, and vacuum-dried Finally, the dry powder of medical sodium hyaluronate refined product is obtained.
Embodiment 2
[0021] Comparative process: Add 2 times the amount of 95% ethanol to 100 L of the filtered complex solution, stir, filter, wash, and vacuum dry to obtain a medical sodium hyaluronate refined product.
[0022] The present invention: 2 times of 95% ethanol is added to the complex solution after 100L filtration, after being stirred and static, 150L of the supernatant is drained, and 100L of 95% ethanol is added, stirred, static, filtered, washed, and vacuum-dried Finally, the dry powder of medical sodium hyaluronate refined product is obtained.
Embodiment 3
[0024] Comparative process: 2 times the amount of 95% ethanol was added to 200L filtered complex solution, and after stirring, filtering, washing and vacuum drying, a medical sodium hyaluronate refined product was obtained.
[0025] The present invention: 2 times of 95% ethanol is added to the complex solution after 200L filtration, after stirring and stilling, 200L of the supernatant is drained, and 200L of 95% ethanol is added, stirred, left still, filtered, washed, and vacuum-dried Finally, the dry powder of medical sodium hyaluronate refined product is obtained.
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Abstract
The invention relates to a method for increasing the yield of a medical sodium hyaluronate refined product. The method comprises the following steps: re-dissolving raw materials; sterilizing and filtering; adding ethanol for ethanol precipitation; filtering; washing; and drying to obtain a dried refined product powder. According to the method, when a re-dissolved solution flows in the ethanol precipitation stage, the concentration of an ethanol precipitation liquid is increased by a method of draining supernatant and adding ethanol, so that precipitated particles cannot be easily adhered and have uniform granularity, and the ethanol precipitation liquid can easily flow through the filter plate of a filtering-washing-drying machine. The method has the advantages of low production cost and short drying time, and can be used for reducing ethanol residues of a refined product and remarkably improving yield, so that the aim of improving yield and quality can be achieved.
Description
technical field [0001] The invention relates to a method for improving the yield of refined medical sodium hyaluronate. Background technique [0002] Alcohol precipitation method is commonly used in the purification and refining method of raw material complex solution. In the production process of medical sodium hyaluronate refined products, the alcohol precipitation method is to use the insoluble characteristics of sodium hyaluronate in ethanol. After a certain amount of ethanol is added to the reconstituted solution after sterilization and filtration, hyaluronic acid is immediately absorbed. Precipitate out. During the precipitation process, impurities in sodium hyaluronate can be removed, and the active ingredients of sodium hyaluronate can be retained. Usually when the alcohol content reaches 60%, sodium hyaluronate starts to precipitate, when the alcohol content reaches 75%, the protein can be removed, when the alcohol content reaches 80%, almost all impurities such a...
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