Medical composition for treating cold and preparation method of medical composition

Abstract

The invention relates to a medical composition for treating cold and a preparation method of the medical composition. The preparation method consists of the following components by weight: 150-250 parts of ibuprofen, 5-15 parts of phenylephrine hydrochloride, 150-250 parts of mannitol, 20-60 parts of croscarmellose sodium, 50-90 parts of saccharose, 100-200 parts of microcrystalline cellulose, 10-20 parts of maltodextrin, 0.5-1.5 parts of propyl gallate, 2.5-7.5 parts of magnesium stearate and 3-5 parts of chlorpheniramine maleate. A preparation method for the two-prescription or three-prescription medical composition comprises the following steps: dissolving ibuprofen into pure water, heating to 70 DEG C, adding mannitol, dissolving, carrying out freeze drying in a freezer dryer, smashing into powder to obtain an ibuprofen and mannitol mixture, then mixing the obtained mixture with other components, and compressing by adopting a direct powder tabletting method to obtain tablets. According to the method, ibuprofen can be dissolved out quickly to achieve the quick effective effect. Through detection, dissolution of ibuprofen, chlorpheniramine maleate and phenylephrine hydrochloride in tablets prepared by adopting the method in 15 min can reach 90% or higher.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition for treating colds and a preparation method thereof. Background technique [0002] Anti-cold medicines are a huge family and the largest category of medicines. This is mainly reflected in the following three aspects: first, the symptoms of colds are various, resulting in a wide variety of compound drug combinations; Drug combinations with the same pharmacological effect but different entities, such as combining with different antihistamines, have formed a variety of compound combinations; the second is that the degree of cold symptoms is different from the individual state of the patient, and the anti-cold medicines of the same prescription are different. There are many different specifications; thirdly, due to factors such as the patient's age and medication compliance, the anti-cold medicine of the same prescription has many different dosa...

AI Technical Summary

Problems solved by technology

[0009] However, ibuprofen is insoluble in water and has a slow onset of action. By comparing the reference preparation (trade name: Advil ? ) test, the dissolution rate of ibuprofen was only 50% in 5 minutes, and did not reach 90% in 15 minutes. The dissolution was slow, the onset was slow, and the pain could not be relieved in time

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