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Oyster calcium carbonate effervescent tablet composition and preparation method thereof

A technology of oyster calcium carbonate and effervescent tablets, applied in the field of medicine, can solve problems such as large specific surface area of ​​nano-calcium carbonate, hyperacidity, discomfort, etc., achieve clear and transparent effervescent time, improve lubricity and anti-adhesiveness, overcome The effect of the sticking problem

Inactive Publication Date: 2018-04-03
SINOPHARM SHANTOU JINSHI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large specific surface area and large static electricity during the preparation process, nano-calcium carbonate is easy to agglomerate
[0009] In addition, the solution of existing calcium carbonate effervescent tablets is slightly acidic after flushing and effervescent. In order to completely dissolve calcium carbonate, the amount of acid source is generally slightly more than the amount of calcium carbonate. It is partially dissolved in the solution, and the pH of the effervescent solution is about 4. After taking it, it may cause hyperacidity and discomfort

Method used

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  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof
  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof
  • Oyster calcium carbonate effervescent tablet composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0039]

[0040] Wherein, the nonionic surfactant is a mixture of polyoxyethylene stearate and polyoxyethylene lauryl ether in a weight ratio of 1:1, the HLB value of the polyoxyethylene stearate is 11.1, and the polyoxyethylene lauryl ether is 1:1 by weight. The HLB value of oxyethylene lauryl ether was 16.0.

[0041] The preparation method is as follows:

[0042] Dissolve povidone with 90wt% ethanol to prepare 780mL of 3wt% povidone solution; dissolve the oil-soluble liquid essence with 90wt% ethanol to prepare 60mL of uniform essence solution; dissolve the nonionic surfactant with 95wt% ethanol, Prepare 30mL of uniform nonionic surfactant solution;

[0043] Mix the above prepared essence solution, nonionic surfactant solution and 200mL povidone solution evenly, then use the mixed solution to make oyster calcium carbonate into a soft material, wet granulate, dry under reduced...

Embodiment 2

[0048] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0049]

[0050] Wherein, the nonionic surfactant is a mixture of polyoxyethylene stearate and polyoxyethylene lauryl ether in a weight ratio of 1:1, the HLB value of the polyoxyethylene stearate is 11.1, and the polyoxyethylene lauryl ether is 1:1 by weight. The HLB value of oxyethylene lauryl ether was 16.0.

[0051] The preparation method is as follows:

[0052] Dissolve povidone with 90wt% ethanol to prepare 945mL of 3wt% povidone solution; dissolve the oil-soluble liquid essence with 90wt% ethanol to prepare 60mL of uniform essence solution; dissolve the nonionic surfactant with an appropriate amount of 95wt% ethanol , prepare 30mL of uniform nonionic surfactant solution;

[0053] Mix the above prepared essence solution, nonionic surfactant solution and 200mL povidone solution evenly, then use the mixed solution to make oyster calcium carbonate into a soft material, wet gr...

Embodiment 3

[0058] Oyster calcium carbonate effervescent tablet composition, by g, is composed as follows:

[0059]

[0060] Wherein, the nonionic surfactant is a mixture of polyoxyethylene stearate and polyoxyethylene lauryl ether in a weight ratio of 1:1, the HLB value of the polyoxyethylene stearate is 11.1, and the polyoxyethylene lauryl ether is 1:1 by weight. The HLB value of oxyethylene lauryl ether was 16.0.

[0061] The preparation method is as follows:

[0062] Dissolve povidone with 90wt% ethanol to prepare 825mL of 3wt% povidone solution; dissolve the oil-soluble liquid essence with 90wt% ethanol to prepare 60mL of uniform essence solution, dissolve the nonionic surfactant with 95wt% ethanol, Prepare 30mL of uniform nonionic surfactant solution;

[0063] Mix the above prepared essence solution, nonionic surfactant solution and 200mL povidone solution evenly, then use the mixed solution to make oyster calcium carbonate into a soft material, wet granulate, dry under reduced...

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Abstract

The invention belongs to the field of medicines, and relates to an oyster shell calcium effervescent tablet composition and a preparation method thereof. The oyster shell calcium effervescent tablet composition comprises the following raw materials in parts by weight: 100 parts of oyster shell calcium, 180-260 parts of an acid source, 50-100 parts of sodium bicarbonate, 1-10 parts of an oil-solubility liquid essence, 1-3 parts of povidone, 1-3 parts of a nonionic surfactant and 2-45 parts of a sweetening agent. The oyster shell calcium effervescent tablet composition can be well effervesced and dissolved; through coordination of the oil-solubility liquid essence and the specific nonionic surfactant, the oyster shell calcium effervescent tablet composition has improved lubricity and bonding resistance; the problem of sticking in pressing of the effervescent tablet is solved; the oyster shell calcium effervescent tablet composition can be produced in a workshop which is below 30 DEG C and of which RH does not exceed 50%; agglomeration of nano calcium carbonate is prevented; the formula of the oyster shell calcium effervescent tablet composition is optimized; the pH value of the effervesced solution is about 5-6; and discomfort caused by hyperacidity is avoided.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to oyster calcium carbonate effervescent tablet composition and a preparation method thereof. Background technique [0002] Calcium is one of the important elements in the human body and has very important physiological and biochemical functions. Calcium is not only the main substance that constitutes bones, but also participates in the metabolism of bones, and is necessary to maintain nerve and muscle functions, and also plays an important role in maintaining normal heart, kidney, lung and blood coagulation functions, as well as the permeability of cell membranes and capillaries It can also regulate the secretion and storage of neurotransmitters and hormones, the uptake and utilization of amino acids, vitamin B 12 absorption etc. The important mechanism for the living cells of the human body to obtain energy is the transmembrane movement of calcium. The calcium content of the normal cell me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K33/10A61K35/618A61K47/44A61K47/10A61K47/14A61K47/32A61P3/02
CPCA61K9/0007A61K9/2027A61K9/2031A61K9/2068A61K33/10A61K35/618
Inventor 陈智强陈丹瑾陈美清陈茂棠陈振华张小华陈榕
Owner SINOPHARM SHANTOU JINSHI PHARMA CO LTD
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