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Parenteral nutritional composition for injection and preparation method thereof

A technology for parenteral nutrition and injection, applied in the field of medicine, can solve problems such as undiscovered, and achieve the effects of enhancing immunity, strong protection, and enhancing myocardial cell function.

Inactive Publication Date: 2016-04-27
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No all-in-one parenteral nutrition formulation containing glutamine has been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Dosing:

[0040] a. Medium and long-chain fat emulsion injection (OO)

[0041] Element Content per 1000ml olive oil 100g medium chain triglycerides 100g glycerin 22.5g egg yolk lecithin 12g sodium oleate 0.3g

[0042] Preparation of the oil phase: under the protection of nitrogen, add the prescribed amount of olive oil and medium-chain triglycerides to the container, heat in a water bath to 70°C, add egg yolk lecithin under high-speed stirring at 8000 rpm to disperse, and prepare an oil phase.

[0043] Preparation of the water phase: heat another 2 / 3 volume of water to 75°C, put it in a container, add glycerin and sodium oleate, stir and mix well, and filter through a 0.45 μm filter membrane to prepare the water phase.

[0044] Preparation of colostrum: Under nitrogen protection, pour the oil phase into the water phase and stir for 25 minutes under high-speed stirring at 10,000 rpm to make colostrum, adjust the pH to 8.5...

Embodiment 2

[0059] (1) Dosing:

[0060] a. Preparation of Medium and Long Chain Fat Emulsion Injection (OO) 1000ml

[0061] Preparation of the oil phase: under nitrogen protection, add 105.0 g of olive oil and 105.0 g of medium-chain triglycerides to the container, heat it in a water bath to 80°C, add 11.0 g of egg yolk lecithin under high-speed stirring at 8000 rpm to disperse it, and prepare into oil phase.

[0062] Water phase preparation: heat 2 / 3 volume of water to 80°C, put it in a container, add 23.0 g of glycerin and 0.35 g of sodium oleate, stir and mix, and filter through a 0.45 μm filter membrane to prepare a water phase.

[0063] Colostrum preparation: Under nitrogen protection, pour the oil phase into the water phase and stir for 10 minutes under high-speed stirring at 20,000 rpm to make colostrum, adjust the pH to 9.0 with sodium hydroxide, add water for injection until fully stirred, and quickly After cooling down to about 35°C, perform high-pressure homogenization.

[0...

Embodiment 3

[0076] (1) Dosing:

[0077] a. Preparation of Medium and Long Chain Fat Emulsion Injection (OO) 1000ml

[0078] Preparation of oil phase: under nitrogen protection, add 110.0 g of olive oil and 110.0 g of medium-chain triglycerides into the container, heat in a water bath to 65°C, add 13.0 g of egg yolk lecithin under high-speed stirring at 9000 rpm to disperse , prepared into an oil phase.

[0079] Preparation of water phase: Heat 2 / 3 volume of water to 65°C, put it in a container, add 23.7g of glycerin and 0.33g of sodium oleate, stir and mix, and filter through a 0.45μm filter membrane to prepare a water phase.

[0080] Colostrum preparation: under nitrogen protection, pour the oil phase into the water phase and stir for 30 minutes under high-speed stirring at 15,000 rpm to make colostrum, adjust the pH to 8.7 with sodium hydroxide, add water for injection until fully stirred, and quickly After cooling down to about 25°C, perform high-pressure homogenization.

[0081] Ho...

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PUM

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Abstract

The invention relates to a medium- and long-chained fat emulsion (OO) / amino acid (16) dipeptide (2) / glucose electrolyte parenteral nutritional composition, containing following ingredients: three cavities of liquid: a first cavity of medium- and long-chained fat emulsion injection (OO) 250 ml; a second cavity of compound amino acid (16) dipeptide (2) injection 500 ml; a third cavity of glucose electrolyte injection 500 ml. The parenteral nutritional composition for injection has the advantage that a formulation of the three cavities and products produced by the preparation process can meet the requirement on all-in-one stability, can also meet the requirements of patients on fat, proteins, carbohydrates and trace elements and are particularly suitable for patients with high catabolism.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medium-long-chain fat emulsion / amino acid (15) dipeptide (2) / glucose electrolyte parenteral nutrition composition for injection and a preparation method thereof. Background technique [0002] Parenteral nutrition should be given in an "all-in-one" manner. The so-called "all-in-one" nutrient solution infusion is a method of scientifically mixing various nutrients, including fat emulsion, amino acids, glucose and trace elements, in the same container and infusing them to the patient at the same time. This infusion method has been proven to be the most reasonable and correct parenteral nutrition infusion method in clinical practice at home and abroad. According to the above theory, when the hospital is carrying out parenteral nutrition, it should first mix various nutrients before infusion to prepare a complete nutritional mixture, and then inject it intravenously in the form of...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61P3/02A61K31/195A61K31/185A61K31/4172A61K31/405A61K31/401A61K31/198A61K31/685A61K31/201A61K33/06A61K33/14A61K33/30
Inventor 韩瑶
Owner HUAREN PHARMACEUTICAL CO LTD
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