66 results about "Polysaccharide catabolism" patented technology

Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.

The present invention relates to a kit and an intervenously administrable preparation, both, with a signal transmitter precursor, an enhancer of precursor uptake, and an inhibitor of neurotransmitter reuptake or signal transmitter catabolism. The kit also contains an appropriate swab for obtaining oral cells suitable for allelic analysis. The intervenous formulation contains similar materials and, in some cases, ethanol. Either the kit composition or the intervenous formulation may be used as guided by a subjects allelic analysis. Collections of particular alleles, especially those relating to neural system are comprehensible in terms of likelihood of success in the administration of an interveinous formulation or ingestion of components of the subject kit.

This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide or any combination thereof, as described herein.

The invention relates to the field of soil remediation and discloses an in-situ bioremediation preparation for heavy metal contaminated soil. The preparation contains fungi and/or bacteria with heavy metal degrading abilities, the fungi refer to at least one of aspergillus niger, rhizomucor variabilis and grey cunninghamella, and the bacteria refer to at least one of bacillus amyloliquefaciens, bacillus licheniformis and bacillus simplex. By using the preparation for in-situ bioremediation of the heavy metal contaminated soil, the problems that the soil needs to move by using a moving method and secondary chemical agent pollution of the cultivated land is easily caused by using a decomposition method can be overcome, at the same time, residual heavy metals in the soil obtained after catabolism through the fungi and/or bacteria can also be fully used, the problem that high residual heavy metals in the soil seriously endanger food safety is solved, the soil micro-ecology is improved, the cultivated ability of soil is more quickly recovered, and the method is relatively low in cost and has broad application prospects.

Nutrient compositions and methods that sustain and promote positive metabolic energy levels in a targeted manner are disclosed. Methods utilize endogenous energy stores (fat oxidation), increase use of those stores (increasing transport rate), increase available energy (increasing the ability to perform ADP to ATP phosphorylation,) as well as decrease catabolism and increase protein synthesis. Compositions are also disclosed, and include Mono- or Dicreatine-HMB salt; Putrescine Dihydrochloride; Alanine; L-Glutamine, which may be combined with Alanine in a 1:2 to 2:1 molecular ratio; Trimethylglycine; and Guanidinopropionic Acid.

The invention discloses Chinese herbal medicinal weight-reducing tea. The weight-reducing tea is prepared from the following Chinese herbal medicinal raw materials: 4 to 10g of hawthorn, 4 to 10g of cassia seed, 2 to 8g of lotus leaves, 3 to 5g of processed polygonum multiflorum, 1 to 3g of white chrysanthemum, 4 to 10g of lily, 3 to 5g of dried tangerine peel, 2 to 4g of mulberry leaves, and 2 to 4g of rose flowers. The weight-reducing tea can be effectively absorbed by a human body when being drunk in a brewing way, and realizes that over much fat in the body can be subjected to catabiosis in time by promoting fat catabolism, and cannot cause diarrhea; and the weight does not bounce after the weight-reducing tea is used, residual fat is prevented from storing in the body, and the weight is maintained in a certain healthy range. The Chinese herbal medicinal weight-reducing tea has certain beautifying effect.

The invention discloses a brewing method of blueberry enzyme. The method comprises the following steps: sorting blueberry fruit raw materials, crushing and adjusting the pH value; carrying out enzymolysis on blueberry fruit pulp; carrying out low-temperature micro-aerobic yeast fermentation, and preliminarily decomposing macromolecular substances; carrying out low-temperature acetic acid bacterium fermentation to remove ethanol generated in yeast fermentation, and further carrying out catabolism on the wild blueberry fruit pulp; and then carrying out low-temperature compound lactic acid bacterium fermentation, carrying out low-temperature chelation, carrying out pressure filtration for juicing, finally carrying out filtration sterilization, bottling and packing. According to the brewing method disclosed by the invention, multi-layer beneficial microbes are used for fermenting and decomposing wild blueberries, and finally blueberry anthocyanin (VMA) is biologically converted into water-soluble oligomeric proanthocyanidin (OPC), thereby improving the bioactivity and utilization ratio of wild blueberry anthocyanin; and meanwhile, multiple beneficial active substances, namely active proteins, active amino acids and active polypeptides, are produced. The blueberry enzyme obtained by the method disclosed by the invention has the characteristics of full-bodied fruit flavor, crimson color, and dense, slightly sour and palatable taste.

The invention provides a N(2)-L-alanyl-glutamine for injection and its preparing method, it has mixed N(2)-L-alanyl-glutamine and mannite to make N(2)-L-alanyl-glutamine whose mess percentage density is 50-100%. The invention has increased the stability of medicine greatly, convenient for transportation and storage, suitable for sicker in catabolism and hypermetabolism condition who needs glutamine.

The invention discloses fermented fiber feed for pigs and a preparation method thereof. The fermented fiber feed for the pigs takes bran and the like as raw materials, and yeasts, bacillus subtilis, bacillus licheniformis, lactobacillus plantarum, lactobacillus reuteri, and other probiotics are selected for compatibility as fermentation bacteria, and a multi-strain mixed fermentation process is adopted. Catabolism of microorganisms can reduce toxin content in fiber materials, increase protein content in fiber materials, and increase nutritional value of fiber materials. Secondly, various kindsof probiotics for compatibility are selected as fermentation bacteria. After solid-state fermentation of bran and other raw materials, the biological feed contains a large number of probiotics capable of improving intestinal health of animals, and the biological feed can improve micro-ecological environment of a gastrointestinal tract after animals are fed. Body's immunity is improved. In addition, the biological feed is rich in lactic acid and very mellow, palatability of the feed can be significantly improved, animal feed intake is increased, rapid growth of animals is promoted, and production capacity of an aquaculture industry is increased.

The invention discloses low-protein fish meal-free grass carp puffed mixed feed which comprises the following raw materials: bean pulp, fermented bean pulp, wheat, rapeseed meal, cottonseed meal, wheat middling, rice bran, soybean oil, fish soluble, monocalcium phosphate, bentonite, zeolite powder, choline chloride, salt, composite vitamins, composite mineral salts, active essentiale, composite microecologics and a composite immunopotentiator. As fish meal is replaced by high-quality animal and plant protein sources, the problem of essential amino acid composition balance is effectively solved; due to addition of the active essentiale such as bile acid, L-carnitine, taurine, plant flavonoids and marine organism active substances, digestion, absorption and catabolism of grass carps to fat can be promoted, and liver and gall diseases can be prevented. As no fish meal is used in the feed, the protein resource is saved, and the cultivation cost can be lowered; and because of low protein, the essential amino acid balance is good, the burden of organs of the grass craps is alleviated, and the diseases can be reduced.

Relating to the soil remediation field, the invention discloses a preparation for in-situ remediation of chlorothalonil contaminated soil. The preparation contains fungi and/or bacteria with chlorothalonil degradation ability. The fungi can be at least one of Aspergillus niger, rhizomucor variabilis and Cunninghamella bertholletiae, and the bacteria can be at least one of Burkholderia zhejiangensis, pseudomonas aeruginosa and Stenotrophomonas maltophilia. According to the invention, the provided preparation is employed for in-situ bioremediation of chlorothalonil contaminated soil, not only overcomes the problems that photochemical degradation is easily limited by illumination conditions and can easily cause secondary chemical reagent pollution to arable land, at the same time makes full use of fungi and/or bacteria for catabolism of chlorothalonil residual in soil, thus solving the problem that high residual chlorothalonil in soil severely endangers food safety. At the same time, the micro-ecology of soil is improved, so that soil can recover farming ability more rapidly. Also, the method is low in cost, thus having broad application prospects.

The invention discloses an analogy method based on an activated sludge purification process of a HPP lattice gas cellular automaton model, comprising the following steps: setting up a corresponding initial model in an activated sludge system and initializing a cellular state; setting a boundary point; and ensuring an evolution rule according to the initial model. The method comprises the reaction process of particles; and the reaction process comprises particle absorption, particle catabolism, particle anabolism and endogenous respiration. Based on an artificial life system and the HPP lattice gas cellular automaton model, the invention designs the evolution rule of an activated sludge cell automaton and realizes the evolution, simulates a circumstance that microorganism absorbs and decomposes organic matters, well simulates the logarithmic phase, the decelerating grow phase and the endogenous respiration phase of an activated sludge growth model curve, well simulates the degradation curve of BOD organic matters, and has a directive function for further recognizing and understanding the saprobia settlement process.

The invention discloses a novel cucumber SNP molecular marker. The mark number of the novel cucumber SNP molecular marker is SLAF7695. According to the novel cucumber SNP molecular marker, the simplified genome depth sequencing technology is utilized, 73100 SLAF labels are obtained totally, 5355 polymorphic markers of three types including SNP, EPSNP and INDEL are obtained through polymorphic analysis, and 140 different markers closely related to cucumber powdery mildew resistance are obtained and mainly concentrated on the first chromosome and the sixth chromosome. Two candidate areas related to powdery mildew resistance characters are successfully located, seven special markers closely linked with cucumber powdery mildew resistance are obtained, 28 genes and related annotation information are obtained through gene annotation, and five genes are related to the functions of defense response, harm response, toxin catabolism, cell stress response and the like. The novel cucumber SNP molecular marker provides a theoretical foundation for exploration of cucumber powdery mildew resisting mechanism and molecular marker assisted selective breeding.

The unexpected expression of tryptophan 2,3-dioxygenase (TDO2) in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TDO2 are provided, as are methods for treating cancer and inhibiting the growth of cancer cells by inhibiting TDO2, as well as pharmaceutical compositions.

The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods of using one or more of those gene products.

Compositions and methods for administering a diet supplement to humans are provided for the enhancement of weight loss, suppression of appetite, prevention of muscle protein catabolism, and providing antioxidants in either a daytime or nighttime formulation. Said diet supplement is comprised of at least a source of Catechins and at least 3% Corosolic Acid. The diet supplement is provided in either daytime or nighttime formulations.

The invention discloses a composite amino acid vitamin injection and the application thereof. Every 1000ml of the composite amino acid vitamin injection comprises 5-40g of L-leucine, 2-30g of L-isoleucine, 2-30g of L-valine, 5-90g of L-alanyl-L-glutamine, 1-5g of L-threonin 1-10g of L-lysine, 1-12g of L-methionine, 1-10g of L-phenylalanine, 0.5-8g of L-tryptophan, 2-30g of L-arginine, 1-10g of L-histidine, 1-100mg of vitamin B6, 0-50mg of vitamin B1 and 0-100mu g of vitamin B12. Aiming at variation of stress, immunity, metabolism and the like of a human body in a perioperative anesthesia period, the composite amino acid vitamin injection achieves the purposes of inhibiting catabolism, promoting anabolism, generating heat and keeping warm, improving body substance energy metabolism and immunity functions and accelerating heal through creative formulae on the basis of enhanced recovery after surgery.

The invention discloses a method for extracting erythritol from an erythritol mother liquor and a special barm strain for the erythritol. The method comprises the following step of adding the barm strain into the erythritol mother liquor for fermentation and purification, wherein the barm strain can be used for catabolism of polyhydric alcohols and saccharides in the erythritol mother liquor except the erythritol. The special barm strain is a candida (Candida sp. SJTU828) CGMCC NO.7323. The erythritol is extracted from the erythritol mother liquor through an industrialization method of biological fermentation and purification, the extraction efficiency is high, the method is friendly to environment, and the waste resource is economized.

The present invention discloses a cattle feed additives, which mainly comprises the acid-base buffer, activating agent, vitamins, macro elements, trace elements and diluent, which is characterized in that the activation selects organic acids and salts, including humic acid, citric acid and its salts; vitamins include vitamin A, vitamin D3, vitamin E and niacin. The ratio of the compound is 0.8 to 2.5 percent of buffer, 1.2 to 4.8 percent of activated agent, 0.4 to 0.8 percent of vitamin, 0.4 to 0.8 percent of ferrous sulfate, 0.1 to 0.2 percent of copper sulfate, 0.2 to 0.6 percent of manganese sulfate, 0.6 to 1 percent of zinc sulfate, 0.01 to 0.05 per thousand of potassium iodide, 0.01 to 0.04 per thousand of drilling chloride, 0.006 to 0.014 pre thousand of sodium selenite, 25 to 35 percent of lettuce (or calcium bicarbonate), 25 to 35 percent of powder (or Oyster shell powder), 15 to 25 percent of salt, the rest is zeolite increased to one hundred percent. The present invention has the advantages that the feed additives can meet the needs of nutrition for the growing of cattle, balance the metabolism and catabolism to enhance the capability for prevention of various diseases, and improve the production capacity and product quality of beef cattle and milk cattle.

The invention discloses a formula of a crispy biscuit serving as meal replacement for losing weight. The formula comprises the following components in percent by mass: 3-10% of quinoa, 3-8% of psyllium seed husks, 5-15% of resistant dextrin, 20-40% of low-gluten flour, 0-10% of fructose, 0-10% of milk powder, 0-20% of eggs, 0-5% of rapeseed oil, 0.1-4% of plant powder, 0.3-1% of soda ash and 0.2-1% of salt. The biscuit is obtained through mixing and baking. The obtained crispy biscuit has the advantages that the psyllium seed husks are adopted, thereby increasing the proportion of water-soluble dietary fiber, greatly enhancing the satiety, controlling the appetite and reducing the intake; and meanwhile, multiple components of barley tender seedlings are utilized for catalyzing, thereby accelerating the catabolism and burning conversion of macromolecular fat tissues in bodies and being favorable for losing weight, reducing fat and controlling body weight.

The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.

The invention relates to a special feed for cyprinus carpio under alkaline water area culture conditions and a preparation method thereof and belongs to the technical field of cyprinus carpio feeds and preparation thereof. The feed is prepared from soybean meal, fish meal, middlings, bean oil, fish oil, phospholipid, choline chloride, sodium dihydrogen phosphate, mineral element premix, multivitamins, methionine, threonine, sodium butyrate, alpha-ketoglutaric acid and N-carbamylglutamic acid according to certain parts by mass. Through adding the sodium butyrate, the acid-base equilibrium of intestinal tracts can be changed, the activity of digestive enzymes is improved, the growth of probiotics is promoted to improve intestinal tract health, and growth is promoted. The alpha-ketoglutaric acid and the N-carbamylglutamic acid can convert ammonia resulting from catabolism of proteins into glutamine and arginine in a metabolism process, and nitrogen generated from metabolism is transferredinto amino acids again for reutilization, so that a toxic action on fish bodies caused by the ammonia and the nitrogen is reduced, and the utilization ratio of the nitrogen is increased; meanwhile, the generated glutamine and arginine can also be used for improving immunizing and oxidation resisting functions of organisms.

The invention relates to a medium- and long-chained fat emulsion (OO)/amino acid (16) dipeptide (2)/glucose electrolyte parenteral nutritional composition, containing following ingredients: three cavities of liquid: a first cavity of medium- and long-chained fat emulsion injection (OO) 250 ml; a second cavity of compound amino acid (16) dipeptide (2) injection 500 ml; a third cavity of glucose electrolyte injection 500 ml. The parenteral nutritional composition for injection has the advantage that a formulation of the three cavities and products produced by the preparation process can meet the requirement on all-in-one stability, can also meet the requirements of patients on fat, proteins, carbohydrates and trace elements and are particularly suitable for patients with high catabolism.