Composite amino acid vitamin injection and application thereof

A compound amino acid and injection technology, which is applied in the field of biomedicine to achieve the effects of accelerating rapid development, improving body material energy metabolism and immune function, and high utilization rate

Active Publication Date: 2018-11-02
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about the compound amino acid vitamin injection of the present invention aimed at the material and energy metabolism characteristics of the perioperative anesthesia period and high utilization rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 compound amino acid vitamin injection (one)

[0053] Compound amino acid vitamin injection (per 1000ml) includes: L-leucine: 20.6g, L-isoleucine: 12.2g, L-valine: 15.2g, L-alanyl-L-glutamine : 25g, L-threonine: 2g, L-lysine (acetate): 3.8g, L-methionine: 3g, L-phenylalanine: 2.8g, L-tryptophan: 1g, L -Arginine: 12g, L-histidine: 2.4g, vitamin B6: 10mg, sodium bisulfite 0.5g, adjust the pH value to 5.5-6.5 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after surgery.

Embodiment 2

[0054] Embodiment 2 compound amino acid vitamin injection (two)

[0055] L-leucine: 40g, L-isoleucine: 30g, L-valine: 30g, L-alanyl-L-glutamine: 10g, L-threonine: 5g, L-lysine Amino acid (acetate): 5g, L-methionine: 2g, L-phenylalanine: 3g, L-tryptophan: 0.5g, L-arginine: 5g, L-histidine: 1g, Vitamin B6: 1mg, Vitamin B1: 1mg, Vitamin B12: 100μg, Sodium bisulfite 0.3g, Na + 10mmol / L, Cl - 10mmol / L, adjust the pH value to 5.5-7.0 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after surgery.

Embodiment 3

[0056] Embodiment 3 compound amino acid vitamin injection (three)

[0057] L-leucine: 5g, L-isoleucine: 2g, L-valine: 2g, L-alanyl-L-glutamine: 5g, L-threonine: 1g, L-lysine Amino acid (acetate): 1g, L-methionine: 1g, L-phenylalanine: 1g, L-tryptophan: 8g, L-arginine: 30g, L-histidine: 10g, vitamin B6: 8mg, vitamin B1: 10mg, vitamin B12: 100μg, sodium bisulfite 0.8g, Na + 80mmol / L, Cl - 80mmol / L, adjust the pH value to 5.5-7.0 with glacial acetic acid, add water for injection to a total of 1000ml. Method of use: 4-8kJ·kg during the operation -1 h -1 Intravenous infusion, according to daily 1.2-2.0g / kg intravenous infusion after operation.

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PUM

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Abstract

The invention discloses a composite amino acid vitamin injection and the application thereof. Every 1000ml of the composite amino acid vitamin injection comprises 5-40g of L-leucine, 2-30g of L-isoleucine, 2-30g of L-valine, 5-90g of L-alanyl-L-glutamine, 1-5g of L-threonin 1-10g of L-lysine, 1-12g of L-methionine, 1-10g of L-phenylalanine, 0.5-8g of L-tryptophan, 2-30g of L-arginine, 1-10g of L-histidine, 1-100mg of vitamin B6, 0-50mg of vitamin B1 and 0-100mu g of vitamin B12. Aiming at variation of stress, immunity, metabolism and the like of a human body in a perioperative anesthesia period, the composite amino acid vitamin injection achieves the purposes of inhibiting catabolism, promoting anabolism, generating heat and keeping warm, improving body substance energy metabolism and immunity functions and accelerating heal through creative formulae on the basis of enhanced recovery after surgery.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound amino acid vitamin injection and its application. Background technique [0002] In the past, the infusion of energy substances (amino acids, fats) other than glucose was considered only when the patient was still unable to eat effectively during the perioperative period. In 2003, the inventor carried out the infusion of compound amino acids during anesthesia Afterwards, the clinical effects of various formula amino acids were studied, and it was found that proper infusion of compound amino acid injection during surgical anesthesia can inhibit the decomposition of skeletal muscle protein, promote its synthesis, inhibit fat mobilization, improve hypothermia caused by surgical anesthesia, and correct Negative nitrogen balance, no obvious side effects, no damage to liver and kidney functions, and can be safely used in diabetic patients. However, currently commercially...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K9/08A61P3/02A61P37/04A61P39/00A61K31/198A61K31/405A61K31/4172A61K31/4415A61K31/51A61K31/714A61K33/04
CPCA61K9/0019A61K9/08A61K31/198A61K31/405A61K31/4172A61K31/4415A61K31/51A61K31/714A61K33/04A61K38/05A61P3/02A61P37/04A61P39/00A61K2300/00
Inventor 葛圣金
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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