Composite medical bio-fiber hemostasis modified material and preparation method thereof

A modified material and bio-fiber technology, which is applied in the field of biomedical hemostatic materials, can solve the problems of limited wide application, insufficient hemostatic speed, and unsatisfactory hemostatic effect, and achieve good drug efficacy, avoid agglomeration, and evenly disperse the effect

Inactive Publication Date: 2016-05-11
GUANGXI XINYE BIOLOGICAL TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the hemostatic effect of these current technologies is not ideal, and the hemostatic speed is not fast enough, which limits its wide application in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] A composite medical biological fiber hemostatic modified material is composed of the following raw materials in weight percentage:

[0081] Collagen 50%

[0082] Puffball spore powder 30%

[0083] Hemostatic Chinese medicine extract 20%.

[0084] The collagen is nanoscale collagen.

[0085] The collagen is medical grade collagen with an average molecular weight of 1000 Daltons.

[0086] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 110 degrees Celsius, crushing and passing through a sieve of more than 100 mesh.

[0087] The hemostatic traditional Chinese medicine extract is a mixture of 10 parts of large thistle extract and 20 parts of small thistle extract.

[0088] The above collagen, puffball spore powder and hemostatic traditional Chinese medicine extract are mixed to obtain a composite medical biofiber hemostatic modified materi...

Embodiment 2

[0090] A composite medical biological fiber hemostatic modified material is composed of the following raw materials in weight percentage:

[0091] Collagen 40%

[0092] Puffball spore powder 40%

[0093] Hemostatic Chinese medicine extract 20%.

[0094] The collagen is nanoscale collagen.

[0095] The collagen is medical grade collagen with an average molecular weight of 500 Daltons.

[0096] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 120 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0097] The hemostatic traditional Chinese medicine extract is a mixture composed of 20 parts of Burnet ulmus extract, 40 parts of Ramie root extract, 30 parts of Sophora japonica extract, 30 parts of Puhuang extract and 25 parts of Agrimony extract.

[0098] Collagen, puffball spore powder and hemostatic tradi...

Embodiment 3

[0101] A composite medical biological fiber hemostatic modified material is composed of the following raw materials in weight percentage:

[0102] Collagen 30%

[0103] Puffball spore powder 40%

[0104] Hemostatic Chinese medicine extract 30%.

[0105] The collagen is nanoscale collagen.

[0106] The collagen is medical grade collagen with an average molecular weight of 1500 Daltons.

[0107] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 130 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0108] The hemostatic traditional Chinese medicine extract is 10 parts of Burnet extract, 20 parts of Rubia extract, 20 parts of Imperata rhizome extract, 10 parts of Cockscomb flower extract, 20 parts of Duanxueliu extract, 5 parts of Liu Jinu extract, A mixture of 10 parts of Purple Pearl Extract.

[0109]...

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Abstract

The invention relates to a biomedical hemostasis material, in particular to a composite medical bio-fiber hemostasis modified material and a preparation method thereof. The material is prepared from collagen, lasiosphaera seu calvatia spore powder and hemostasis traditional Chinese medicine extract. Collagen can be rapidly combined with hemoglobin in blood to form hemostasis clots. A large amount of micro porous fiber is stored in lasiosphaera seu calvatia spore powder and can rapidly absorb moisture in blood so that blood vessel cracks and blood capillary blood oozing can be mechanically blocked. A physical barrier is formed by the two substances, isolates wounds and plays a role in adhesion prevention and immediate hemostasis. Extract of the hemostasis traditional Chinese medicine extract has the effects of hemostasis, inflammation resistance, bacterium resistance, analgesia, blood cooling, stasis eliminating, swelling reducing, convergence, coagulation system activation and wound healing promotion. The three substances are organically combined, and the material is remarkable in hemostasis effect, is used for wound surface blood oozing of various types of wounds and fresh tissue, small blood vessel bleeding and hemostasis in bleeding areas, can prevent adhesion and is particularly suitable for hemostasis in surgery.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to a composite medical biological fiber hemostatic modified material and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the s...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61K36/899A61P7/04A61P17/02A61K35/36
CPCA61L26/0033A61K35/36A61K36/14A61K36/185A61K36/19A61K36/21A61K36/258A61K36/28A61K36/282A61K36/48A61K36/489A61K36/53A61K36/56A61K36/62A61K36/66A61K36/704A61K36/73A61K36/739A61K36/74A61K36/80A61K36/85A61K36/88A61K36/898A61K36/899A61L26/0057A61L26/0066A61L26/009A61L2300/30A61L2300/418C08L89/06A61K2300/00
Inventor 梁奕福
Owner GUANGXI XINYE BIOLOGICAL TECH
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