Local anesthesia gel preparation and preparation method thereof

A technology of local anesthetics and gel preparations, applied in the field of anesthetics, can solve the problems of flammability and peroxides, and achieve the effects of rapid action, good affinity, and reduced local damage

Inactive Publication Date: 2016-06-01
卢连伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it is flammable and will produce peroxide if left for too long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A gel preparation for local anesthesia, which is composed of the following raw materials in parts by weight: 8 parts of snake vine, 8 parts of benzoin, 2 parts of bee venom, 0.1 part of ethylamine, 0.3 part of benzoate, and 3 parts of menthol , 2 parts of diclofenac, 1.0 part of sodium fusidate, 1.5 parts of local anesthetic, 2.3 parts of viscous polymer, 0.05 part of preservative, 0.05 part of antioxidant, 0.2 part of surfactant, and 10 parts of gel matrix.

[0022] Wherein, the local anesthetic is lidocaine. The viscous polymer is polyanionic cellulose, which has better stabilizing and thickening effects, as well as antibacterial and water-retaining effects. The preservative is benzalkonium chloride, which effectively prevents drug corruption and prolongs the shelf life. The antioxidant is riboflavin, which is effective in anti-oxidation and prevents the degradation of easily oxidized components. The surfactant is polyoxygenated 10-alcohol-ether, which has better so...

Embodiment 2

[0029] A gel preparation for local anesthesia, which is composed of the following raw materials in parts by weight: 14 parts of snake vine, 14 parts of benzoin, 2.4 parts of bee venom, 1.05 parts of ethanamine, 0.65 parts of benzoate, and 4 parts of menthol , 2.8 parts of diclofenac, 1.25 parts of sodium fusidate, 2.5 parts of local anesthetic, 3.15 parts of viscous polymer, 0.175 parts of preservative, 0.75 part of antioxidant, 0.4 part of surfactant, and 13 parts of gel matrix.

[0030] Wherein, the local anesthetic is prilocaine. The viscous polymer is polyanionic cellulose, which has better stabilizing and thickening effects, as well as antibacterial and water-retaining effects. The preservative is chlorobutanol, which effectively prevents drug corruption and prolongs the shelf life. The antioxidant is riboflavin, which is effective in anti-oxidation and prevents the degradation of easily oxidized components. The surfactant is Tween 80, which plays a better solubilizing ...

Embodiment 3

[0037] A gel preparation for local anesthesia, which is composed of the following raw materials in parts by weight: 20 parts of snake vine, 20 parts of benzoin, 2.8 parts of bee venom, 2.0 parts of ethanamine, 1.0 parts of benzoate, and 5 parts of menthol , 3.6 parts of diclofenac, 1.5 parts of sodium fusidate, 3.5 parts of local anesthetic, 4.0 parts of viscous polymer, 0.3 part of preservative, 0.1 part of antioxidant, 0.6 part of surfactant, and 16 parts of gel matrix.

[0038] Wherein, the local anesthetic is benzocaine. The viscous polymer is polyanionic cellulose, which has better stabilizing and thickening effects, as well as antibacterial and water-retaining effects. The preservative is benzalkonium chloride, which effectively prevents drug corruption and prolongs the shelf life. The antioxidant is riboflavin, which is effective in anti-oxidation and prevents the degradation of easily oxidized components. The surfactant is ethanol, which plays a better solubilizing e...

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PUM

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Abstract

The invention discloses local anesthesia gel preparation and a preparation method thereof. The local anesthesia gel preparation is prepared from, by weight, 8-20 parts of Celastrus orbiculatus, 8-20 parts of benzoin, 2-2.8 parts of bee venom, 0.1-2.0 parts of etamsylate, 0.3-1.0 part of benzoate, 3-5 parts of menthol, 2-3.6 parts of diclofenac, 1.0-1.5 parts of sodium fusidate, 1.5-3.5 parts of local anesthetic, 2.3-4.0 parts of viscous polymer, 0.05-0.3 part of preservative, 0.05-0.1 part of antioxidant, 0.2-0.6 part of surfactant and 10-16 parts of gel matrix. The local anesthesia gel preparation can be used for local administration of trauma or during small external surgery, can play a good role in controlling pain, resisting bacteria, diminishing inflammation and preventing wound infection, can reduce local damage, has high affinity with skin and is convenient to use and quick in action; anesthetic action generated by the local anesthesia gel preparation can quickly seep into collenchyme and can last for a long time, and the local anesthesia gel preparation is safe and nontoxic, simple in preparation process and low in cost.

Description

technical field [0001] The invention relates to the technical field of anesthetics, in particular to a local anesthetic gel preparation and a preparation method thereof. Background technique [0002] Anesthetics refer to drugs that can cause temporary and reversible loss of consciousness and pain in the whole body or parts of the body. According to their scope of action, they can be divided into general anesthetics and local anesthetics, and general anesthetics and local anesthetics can be further divided into inhalational anesthetics and intravenous anesthetics according to their different action characteristics and administration methods. Anesthetics are divided into general anesthetics and local anesthetics. General anesthetics inhibit the cerebral cortex from shallow to deep, making people lose their consciousness. Local anesthesia can stabilize the membrane potential of the nerve or reduce the permeability of the membrane to sodium ions, block the conduction of nerve ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K9/06A61P23/02A61K31/56A61K31/216A61K31/196A61K31/045A61K35/64
CPCA61K36/37A61K9/0014A61K9/06A61K31/045A61K31/167A61K31/196A61K31/205A61K31/216A61K31/245A61K31/56A61K35/63A61K36/185A61K47/32A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 卢连伟
Owner 卢连伟
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