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Anti-anginal traditional Chinese medicine composition and preparation method thereof

A composition and technology for angina pectoris, which are applied in directions such as drug combination, drug delivery, and pharmaceutical formulation, can solve the problems of low curative effect, long treatment time, cure coronary heart disease, etc. Effect

Inactive Publication Date: 2016-06-15
姜少燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the western medicines for treating coronary heart disease and heart pain are mainly nitrate compounds, beta-receptor blockers and calcium antagonists, etc. These medicines can only relieve symptoms, are difficult to cure the root cause, and have certain toxic and side effects; while traditional Chinese medicine is currently clinically Most of the Chinese patent medicines used in the treatment of coronary heart disease and angina pectoris, such as Compound Danshen Tablets and Danqi Tablets, also have the defects of incomplete medication, low curative effect, and slow onset of action, and often need to be used in combination with multiple drugs
Although the single-target effect of traditional Chinese medicine is lower than that of western medicine, its multi-channel, multi-target, dynamic overall treatment, and less toxic and side effects are far beyond the reach of western medicine.
However, conventional traditional Chinese medicine treatment takes a long time, and it is difficult to fundamentally cure coronary heart disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) an anti-angina pectoris traditional Chinese medicine, which is formed by the following raw materials by weight:

[0038] 30 servings of Chuanqiong, 25 servings of flat buds, 20 servings of wormwood, 15 servings of lotus seed heart, 15 servings of honeysuckle, 10 servings of salvia, 10 servings of Yuanhu, 10 servings of large bone, 10 servings of cassia seeds, 5 servings of prickly ginseng, angelica 5 servings.

[0039] (2) Preparation method:

[0040] The first step, Chuanqiong, flat buds, and wormwood firewood are mixed in proportion, and the n-propanol with an alcohol concentration equivalent to 2-3 times of the mixture quality is 70-80% n-propanol reflux extraction 2-4 times, merge the filtrate, reduce the pressure. Concentrate, dry and pulverize into powder, then purify 1-2 times with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to paste with relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0041]...

Embodiment 2

[0045] (1) a kind of Chinese medicine of anti-angina pectoris, is formed by following raw material medicine proportion by weight: with embodiment 1.

[0046] (2) Preparation method:

[0047] The first step, Chuanqiong, flat buds, and wormwood firewood are mixed in proportion, and the n-propanol with an alcohol concentration equivalent to 2-3 times of the mixture quality is 70-80% n-propanol reflux extraction 2-4 times, merge the filtrate, reduce the pressure. Concentrate, dry and pulverize into powder, then purify 1-2 times with ethanol, combine the extracts, recover ethanol under reduced pressure and concentrate to paste with relative density of 1.21-1.24 at 60°C, dry and pulverize into powder;

[0048] In the second step, lotus seed heart, honeysuckle, salvia miltiorrhiza, and fenugreek are extracted 2-3 times with n-propanol with an alcohol concentration of 80-90%, and the extracts are combined, concentrated under reduced pressure, dried, and pulverized into powder. The po...

Embodiment 3

[0052] 1. Long-term toxicity test process:

[0053] Using Wistar rats (provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd.), the experimental drugs are set to three doses of high, medium and low, which are respectively the capsules 8g / kg, 4g / kg, 2g of the formula of Example 1. / kg. Calculated according to the human dose of 0.1g / kg / day, it is 80 times, 40 times and 20 times the effective dose for human use, respectively; another control group was set up by continuous intragastric administration for 90 days, 180 days and some animals were discontinued for 10 days. Days later, the effects on various physiological and biochemical indexes of rats were observed. The experimental results show that: different doses are administered orally to rats for 180 days, and there is no effect on the food intake and body weight increase of rats. No obvious toxic effects were found on liver and kidney function. There was no significant effect on blood routine, blood bioche...

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Abstract

The invention discloses an anti-angina pectoris Chinese medicine composition, which comprises: Chuanqiong, Bianlei, Chongdouchai, Lianzixin, honeysuckle, Danshen, Yuanhu, Dabogu, cassia, ginseng and angelica. A preparation method of the above-mentioned traditional Chinese medicine composition is disclosed. The use of the traditional Chinese medicine composition has the advantages of good curative effect, low cost, high cure rate, no adverse reaction and the like in antiangina pectoris. The present invention makes full use of the medicinal properties and efficacy of the above-mentioned various medicines, can enhance the physical fitness of patients, has the effects of calming the mind and calming the nerves, promoting blood circulation and removing blood stasis, promoting qi and relieving pain, consolidating the body and cultivating the essence, and the production process is simple, with little toxic and side effects, It is easy to manufacture, has cheap raw materials, simple preparation method, has good anti-angina pectoris effect, and can be widely used in clinical practice.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a traditional Chinese medicine composition for anti-angina pectoris and a preparation method thereof. Background technique [0002] Angina pectoris is a clinical syndrome mainly characterized by paroxysmal chest pain or chest discomfort caused by coronary insufficiency, myocardial acute, temporary ischemia and hypoxia. It is characterized by paroxysmal and compressive pain in the anterior chest, which may be accompanied by other symptoms. The pain is mainly located at the back of the sternum and can radiate to the precordial area and left upper limb. It often occurs during labor or emotional agitation, and each attack lasts for 3 to 5 minutes. , It can be once a few days, or several times a day, and disappear after rest or nitrate preparations. The disease is more common in men, most of whom are over 40 years old. Fatigue, emotional agitation, overeating, cold, rainy weather, and acute c...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P9/10
CPCA61K36/236A61K9/0019A61K9/08A61K9/4858A61K36/19A61K36/232A61K36/25A61K36/355A61K36/48A61K36/482A61K36/515A61K36/537A61K36/62A61K36/66A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 姜少燕
Owner 姜少燕
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