Transition metal disulfide compound nano sheet layer with good biocompatibility as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of function materials, in particular to a transition metal disulfide compound nano sheet layer with good biocompatibility as well as a preparation method and application thereof. A polymer modified nano sheet layer of a transition metal disulfide compound is obtained by performing ultrasonic exfoliation on transition metal disulfide compound powder through the polymer-assisted aqueous phase, and can serve as a non-poisonous and efficient photothermal therapeutic agent. In the preparation of the nano sheet layer, no organic solvent is needed, a green water phase exfoliation method is adopted, the operation is simple, the production cost is low, large-scale industrial application is easily realized, and the prepared transition metal disulfide compound nano sheet layer is good in biocompatibility, has a good effect on treatment in vitro of cancer cells, and has the large-scale preparation capacity and a wide biomedical prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a transition metal dichalcogen compound nanosheet with good biocompatibility, a preparation method thereof and its biological application as a high-efficiency photothermal therapeutic agent. Background technique [0002] In recent years, the incidence of cancer has shown a significant increase in our country. As the main treatment methods for cancer at present, radiotherapy and chemotherapy have poor therapeutic effects and are accompanied by high toxic and side effects, which leads to the current low cure rate of cancer. Therefore, it is extremely necessary to break through the existing thinking, develop new drugs and treatment methods, and improve the safety of treatment and the cure rate of cancer cells. The hyperthermia method for tumor treatment has received more and more attention due to its high safety. Scientific research has found that high tem...

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Problems solved by technology

In 2011, "Science" (Science, 2011, 331, 568) first proposed liquid phase stripping technology. They believed that some high boiling point solvents have similar surface energy to transition metal dichalcogenides, so they can effectively strip transition metal dichalcogenides. compound to prepare its nanosheets. This method is easy to operate, but high-boiling organic solvents may cause pollution problems in industrial production, and post-processing is more troublesome. Therefore, a green and environmentally friendly aqueous phase stripping transition metal dichalcogenide technology is developed. It will have a broader prospect of industrial application

So far, there are few research reports in this area. In 2011, "Advanced Materials" (Advanced Materials, 2011, 23, 3944–3948) reported a method of exfoliating two-dimensional sheet materials with an aqueous solution of sodium cholate surfactant, which subsequently caused However, most of the current research is limited to the aqueous phase exfoliation of transition metal dichalcogenides, and there are few further applications of exfoliated nanosheets.

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