Transition metal disulfide compound nano sheet layer with good biocompatibility as well as preparation method and application thereof

A biocompatibility, transition metal technology, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc. for materials and surface science, can solve the problem of less research on the application of nanosheets, troublesome post-processing, and high boiling point organic solvents Pollution and other problems, to achieve the effect of broad industrial application prospects, short production cycle, and convenient operation process

Inactive Publication Date: 2016-06-15
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In 2011, "Science" (Science, 2011, 331, 568) first proposed liquid phase stripping technology. They believed that some high boiling point solvents have similar surface energy to transition metal dichalcogenides, so they can effectively strip transition metal dichalcogenides. compound to prepare its nanosheets. This method is easy to operate, but high-boiling organic solvents may cause pollution problems in industrial production, and post-processing is more troublesome. Therefore, a green and environmentally friendly aqueous phase stripping transitio...

Method used

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  • Transition metal disulfide compound nano sheet layer with good biocompatibility as well as preparation method and application thereof
  • Transition metal disulfide compound nano sheet layer with good biocompatibility as well as preparation method and application thereof
  • Transition metal disulfide compound nano sheet layer with good biocompatibility as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Disperse 1 g of molybdenum diselenide powder and 0.5 g of PVP in 250 mL of water, sonicate for 8 hours, and collect the supernatant by centrifuging the ultrasonic solution to obtain a non-covalently modified molybdenum diselenide nanosheet aqueous solution. The prepared nanosheet aqueous solution can be centrifuged at 3000 rpm for 30 minutes at a high speed, and then freeze-dried for 24 hours to further separate the nanosheets of PVP-modified molybdenum diselenide, which can be used as an efficient and non-toxic photothermal therapeutic agent.

[0023] From figure 1 It can be seen that the exfoliated molybdenum diselenide nanosheets have good stability in water.

[0024] From figure 2 It can be seen that the molybdenum diselenide nanosheet layer has very little toxicity to normal cells, which proves that it has good biocompatibility.

[0025] From image 3 can be seen through the 2.5Wcm -2 After 10 minutes of 808nm photothermal treatment, the survival rate of cance...

Embodiment 2

[0027] Disperse 1 g of molybdenum disulfide powder and 0.5 g of PVP in 250 mL of water, sonicate for 8 hours, and collect the supernatant by centrifuging the ultrasonic solution to obtain a non-covalently modified molybdenum disulfide nanosheet aqueous solution of PVP. The prepared nanosheet aqueous solution can be centrifuged at 3000 rpm for 30 minutes at a high speed, and then freeze-dried for 24 hours to further separate to obtain nanosheets of polymer-modified molybdenum disulfide, which can be used as an efficient and non-toxic photothermal therapeutic agent.

Embodiment 3

[0029] Disperse 1 g of tungsten disulfide powder and 0.5 g of PVP in 250 mL of water, sonicate for 8 hours, and collect the supernatant by centrifuging the ultrasonic solution to obtain a nanosheet aqueous solution of tungsten disulfide non-covalently modified by PVP. The prepared nanosheet aqueous solution can be centrifuged at 3000 rpm for 30 minutes at a high speed, and then freeze-dried for 24 hours to further separate to obtain nanosheets of polymer-modified tungsten disulfide, which can be used as an efficient and non-toxic photothermal therapeutic agent.

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Abstract

The invention belongs to the technical field of function materials, in particular to a transition metal disulfide compound nano sheet layer with good biocompatibility as well as a preparation method and application thereof. A polymer modified nano sheet layer of a transition metal disulfide compound is obtained by performing ultrasonic exfoliation on transition metal disulfide compound powder through the polymer-assisted aqueous phase, and can serve as a non-poisonous and efficient photothermal therapeutic agent. In the preparation of the nano sheet layer, no organic solvent is needed, a green water phase exfoliation method is adopted, the operation is simple, the production cost is low, large-scale industrial application is easily realized, and the prepared transition metal disulfide compound nano sheet layer is good in biocompatibility, has a good effect on treatment in vitro of cancer cells, and has the large-scale preparation capacity and a wide biomedical prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a transition metal dichalcogen compound nanosheet with good biocompatibility, a preparation method thereof and its biological application as a high-efficiency photothermal therapeutic agent. Background technique [0002] In recent years, the incidence of cancer has shown a significant increase in our country. As the main treatment methods for cancer at present, radiotherapy and chemotherapy have poor therapeutic effects and are accompanied by high toxic and side effects, which leads to the current low cure rate of cancer. Therefore, it is extremely necessary to break through the existing thinking, develop new drugs and treatment methods, and improve the safety of treatment and the cure rate of cancer cells. The hyperthermia method for tumor treatment has received more and more attention due to its high safety. Scientific research has found that high tem...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/32A61P35/00B82Y30/00B82Y5/00
CPCA61K41/0052A61K47/32B82Y5/00B82Y30/00
Inventor 雷周玥朱文成徐胜杰武培怡
Owner FUDAN UNIV
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