Gramine analogue with heterocyclic structure and application of gramine analogue with heterocyclic structure to preparation of anti-CVB3 virus medicines

Abstract

The invention relates to a gramine analogue with a heterocyclic structure and application of the gramine analogue with the heterocyclic structure to preparation of anti-CVB3 virus medicines.A chemical formula of the gramine analogue with the heterocyclic structure is as shown in the specification.According to anti-CVB3 activity research experiments of the gramine analogue with the heterocyclic structure, anti-CVB3 pharmacological researches and experiments of CVB3 replication inhibition effect of an analogue G19, the gramine analogue with the heterocyclic structure inhibits CPE (cytopathic effect) of CVB3 on a host cell Hep-2, increases cell survival rate, inhibits progeny virus production and viral nucleic acid generation, mainly inhibits an early replication stage of CVB3 viruses in the host cell and can be applied to preparation of the anti-CVB3 virus medicines.

Description

technical field [0001] The technical field of antiviral drugs of the present invention relates to the application of a Gramine analogue with a heterocyclic structure in the preparation of anti-CVB3 virus drugs. Background technique [0002] Coxsackievirus (Coxsaekievirus) is a member of the genus Enterovirus of the family Picornaviridae, and its infection can cause a variety of diseases, such as hand, foot and mouth disease, aseptic meningitis, encephalitis, myocarditis, epidemic Myositis pain, herpetic angina, etc. There are 29 serotypes of CV reported, which can be divided into two groups, A and B, according to their pathogenic characteristics and cell sensitivity to suckling mice, namely CVA (CVA1-22, 24) and CVB ( CVB1-6). CVBs infection is the most common, among which CVB3 is the most pathogenic type among the six serotypes of CVB, and is the main cause of viral myocarditis. According to the statistics of the US Centers for Disease Control and Prevention (CDC), CVB (...

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Problems solved by technology

Gramine, as a natural indole alkaloid, has been isolated from various plant materials and coal tar, and exhibits a wide range of pharmaceutical activities, such as rela

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