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Composite external use dressing rich in collagen and hyaluronic acid

A collagen and hyaluronic acid technology, applied in the field of cosmetic and plastic medicine products, can solve the problems of weak bioremediation activity, easy to cause allergy rate, no bioremediation activity, etc., to promote healing, reduce irritation and allergy rate, The effect of improving transdermal absorption efficiency and bioremediation activity

Inactive Publication Date: 2016-08-10
BEIJING HEALTH & BIOTECH (H&B) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to avoid the reproduction of bacteria, the original solution or essence containing collagen and human-like collagen contains a certain solubility of preservatives, which are irritating to human skin and easily lead to allergies, which inhibits the product to a certain extent. Efficacy
[0004] Moreover, the existing sticking products have the problems of low transdermal absorption efficiency, no bioremediation activity or weak bioremediation activity

Method used

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  • Composite external use dressing rich in collagen and hyaluronic acid
  • Composite external use dressing rich in collagen and hyaluronic acid
  • Composite external use dressing rich in collagen and hyaluronic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Step 1, pre-sterilizing the non-woven fabric layer 5 and the independent packaging container 3 as the outer packaging by cobalt-60 irradiation, and the irradiation dose is 10kGy;

[0079] Step 2, measure ultrapure water with a mass fraction of 50% of the total mass in the production environment of a class 100 clean workshop;

[0080] Step 3, measuring hyaluronic acid with a mass fraction of 0.5% of the total mass in the production environment of a class 100 clean workshop and dissolving it in the water measured in step 2;

[0081] Step 4, after the hyaluronic acid is completely dissolved, measure allantoin with a mass fraction of 0.1% of the total mass in the production environment of a class 100 clean workshop, and dissolve it in the solution obtained in step 3;

[0082] Step 5, after the allantoin is completely dissolved, measure collagen with a mass fraction of 1.5% of the total mass in the production environment of a class 100 clean workshop, and dissolve it in the ...

Embodiment approach

[0087] In this embodiment 2, except that the collagen complex solution and the preparation method are different from the above-mentioned embodiment, the others are the same. In the above embodiments, the collagen composite solution 4 only contains collagen, hyaluronic acid, and allantoin. In this embodiment, in addition to collagen, hyaluronic acid, and allantoin, butylene glycol, glycerol, and glyceryl polyacrylate were added. In terms of mass percentage, the contents thereof are respectively 2% of butylene glycol; 2% of glycerol; and 0.5% of polyacrylic acid glyceride.

[0088] Same as the above examples, collagen is human-like collagen produced by genetic engineering; hyaluronic acid is hyaluronic acid produced by genetic engineering and microbial fermentation.

[0089] Another preparation method of the dressing of the present invention will be described through examples below.

Embodiment 2

[0091] Step 1, pre-sterilizing the non-woven fabric layer 5 and the independent packaging container 3 as the outer packaging by cobalt-60 irradiation, and the irradiation dose is 10kGy;

[0092] Step 2, measure ultrapure water with a mass fraction of 50% of the total mass in the production environment of a class 100 clean workshop;

[0093] Step 3, in the production environment of the 100-level clean workshop, measure the butanethritol whose mass fraction is 2% of the total mass and dissolve it in the water measured in step 2;

[0094] Step 4, until the butylene glycol is completely dissolved, measure glycerol with a mass fraction of 2% of the total mass in the production environment of a class 100 clean workshop and dissolve it in the water measured in step 3;

[0095] Step 5, until the glycerin is completely dissolved, measure glycerol polyacrylate with a mass fraction of 0.5% of the total mass in the production environment of a class 100 clean workshop and dissolve it in th...

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Abstract

The invention discloses an external dressing rich in collagen and hyaluronic acid, which comprises a non-woven fabric layer 5, a collagen composite solution 4 and an independent packaging container 3. The nonwoven fabric layer 5 is soaked in the collagen complex solution 4 . Collagen compound solution 4 includes the following components, human-like collagen 1-2%; hyaluronic acid 0.3-0.8%; allantoin 0.05%-0.25%; the balance of water. Hyaluronic acid is hyaluronic acid produced by genetic engineering and microbial fermentation; allantoin is allantoin extracted and synthesized by chemical synthesis; water is ultrapure water with a resistivity of 18.2MΩ*cm or greater at 25°C . The products are produced, internally and externally packaged in a class 100 clean workshop, and the finished product is sterilized by cobalt-60 irradiation. By adding appropriate concentrations of human-like collagen, hyaluronic acid and allantoin, it achieves the effect of moisturizing and promoting skin wound healing. At the same time, the present invention greatly reduces the irritation and allergy rate of the dressing by means of irradiation sterilization without adding antiseptic system.

Description

technical field [0001] The invention relates to the field of cosmetic and plastic medicine products, in particular to a composite external dressing rich in collagen and hyaluronic acid and a preparation method. Background technique [0002] Collagen is a high-molecular protein that is generally white, opaque, and fibrous. It is one of the main components of the human body structure, and it is also a necessary substance to delay the aging of the human body. It is widely distributed in the skin, bones, cartilage, muscles, joints and hair tissues of the human body, and can support organs, protect the body and repair function. Human-like collagen is produced by reverse-transcribing the mRNA of human collagen into cDNA, recombining a section of the gene after enzyme digestion into E.coli (Escherichia coli), and producing it through high-density fermentation, separation, renaturation, and purification processes. High molecular bioprotein. It has good bioabsorption, cell adhesio...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/20A61L15/26A61L15/40A61L15/44A61K8/02A61K8/73A61K8/65A61K8/49A61Q19/00
CPCA61L15/325A61K8/0212A61K8/4946A61K8/65A61K8/735A61K2800/592A61L15/20A61L15/26A61L15/28A61L15/40A61L15/44A61L2300/412A61Q19/00
Inventor 杨振亚韩之海刘玢
Owner BEIJING HEALTH & BIOTECH (H&B) CO LTD
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