Qingyangshen total glycosides solid dispersion and its preparation

A technology of total ginseng glucosides and solid dispersion technology, applied in the field of medicine, can solve the problems of unsatisfactory absorption of active ingredients, no solid dispersion of ginseng ginseng total glucosides, etc., so as to improve poor oral absorption, reduce toxic and side effects, The effect of high dissolution

Active Publication Date: 2019-03-26
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the absorption of the active ingredient in the body after oral administration of the formulation is not satisfactory
So far, no related reports on the solid dispersion of total glucosides of Qingyangshen and its preparations have been found

Method used

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  • Qingyangshen total glycosides solid dispersion and its preparation
  • Qingyangshen total glycosides solid dispersion and its preparation
  • Qingyangshen total glycosides solid dispersion and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation of embodiment 1 solid dispersion

[0051] Take total glucosides of Qingyangshen and poloxamer 188 with a mass ratio of 1:1, first heat the carrier material in a water bath at 50°C, after the carrier material is completely melted, add total glucosides of Qingyangshen, stir evenly, and place quickly Stir quickly on an ice-water bath to solidify, then place the solidified product at -20°C for 4 hours, take it out, crush it, and dry it in vacuum for 24 hours, take it out, crush it, and pass it through a 80-mesh sieve to obtain the solid dispersion of total glucosides of Qingyangshen body.

Embodiment 2

[0052] The preparation of embodiment 2 solid dispersion

[0053] Take total glycosides of Qingyangshen and polyoxyethylene 40 stearate with a mass ratio of 1:2, first heat the carrier material in a water bath at 60°C, after the carrier material is completely melted, add total glucosides of Qingyangshen and stir evenly , quickly placed on an ice-water bath, stirred quickly to solidify, and then placed the solidified product at -15°C to continue solidifying for 4 hours, took it out, pulverized it, dried it in vacuum for 18 hours, took it out, pulverized it, and passed through an 80-mesh sieve to obtain Qingyang ginseng total Glycoside solid dispersion.

Embodiment 3

[0054] The preparation of embodiment 3 solid dispersion

[0055] Take total glycosides of Qingyangshen and polyoxyethylene 40 stearate with a mass ratio of 1:3, first heat the carrier material in a water bath at 60°C, after the carrier material is completely melted, add total glucosides of Qingyangshen, and stir evenly , quickly put it on an ice-water bath, stir quickly to solidify, then place the solidified product at -10°C for 6 hours, take it out, crush it, and dry it in vacuum for 24 hours. Glycoside solid dispersion.

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Abstract

The invention relates to Qingyangshen total glycosides solid dispersion and a preparation thereof. The Qingyangshen total glycosides solid dispersion is made with Qingyangshen total glycosides and a carrier material, wherein a weight ratio of the Qingyangshen total glycosides to the carrier material is 1:1-1:5. The invention also relates to the preparation made with the solid dispersion. Compared with the prior art, the Qingyangshen total glycosides solid dispersion and the preparation thereof can solve the problems that Qingyangshen total glycosides is poor in water solubility, an existing preparation is low in absorption and utilization rate, dosage is high and acting speed is low and have the advantages of safety, stability and high carrying capacity, and the preparation process is simple and suitable for industrial production.

Description

technical field [0001] The invention relates to a solid dispersion of Qingyangshen total glycosides and a preparation thereof, belonging to the technical field of medicines. Background technique [0002] Qingyang ginseng is the tuber root of Cynanchum otopphyllum Scheid, a plant of the Radixaceae family. Its medicinal ingredient is qingyang ginseng saponin, which has the effects of calming the liver and tonifying the kidney, eliminating phlegm and spasm, and calming epilepsy; it is used for epilepsy, headache Dizziness, headache, dizziness, tinnitus, soreness of the waist and knees, etc. Commercially available Qingyangshen Tablets are recorded in the Ministry of Health of the People's Republic of China Drug Standards Traditional Chinese Medicine Prescription Volume 12 WS3-B-2343-97, which is a tablet made of Qingyangshen total glycosides and auxiliary starch. The tablet contains 100mg of total glycosides of Qingyangshen, and its usage and dosage is oral, 4-8 tablets at a ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/14A61K47/10A61K9/20A61K9/48A61K9/16A61K36/27A61P25/08A61P25/00A61P29/00A61P1/08A61P27/16
CPCA61K9/145A61K9/146A61K9/1652A61K9/2054A61K9/4866A61K36/27
Inventor 钱一鑫康冀川何珺王鲁
Owner GUIZHOU UNIV
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