Rapid non-destructive tissue biopsy method and technique based on spatial frequency domain-modulated large area resolution microstructure

A technology of tissue biopsy and microstructure, applied in image detector methods and image signal processing, material analysis, material analysis through optical means, etc., can solve the problems of inability to achieve the accuracy and high resolution of optical imaging systems

Active Publication Date: 2016-08-17
WENZHOU MEDICAL UNIV
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Problems solved by technology

In particular, high spatial frequency domain imaging HSFDI can improve the resolution of imaging and quantitatively extract the phase function of light scattering. The problem with HSFDI is the lack of a suitable model that can describe the light reflection coefficient in high spatial frequency analysis.
In addition, traditional SFDI structures cannot achieve the accuracy and high resolution required by optical imaging systems

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  • Rapid non-destructive tissue biopsy method and technique based on spatial frequency domain-modulated large area resolution microstructure
  • Rapid non-destructive tissue biopsy method and technique based on spatial frequency domain-modulated large area resolution microstructure
  • Rapid non-destructive tissue biopsy method and technique based on spatial frequency domain-modulated large area resolution microstructure

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Embodiment Construction

[0023] Embodiments of the present invention will be further described below in conjunction with accompanying drawings:

[0024] The scattering of light in turbid media (such as biological tissue) is a complex process, and the propagation of light can be accurately described by the Boltzmann Radiation Equation (RTE), but its calculation is time-consuming and difficult to apply at present. In addition, the diffusion approximation equation of RTE is only valid when the distance between the light source and the detector is more than 3 / 4 times of the transmission step length, and it is invalid when the distance between the light source and the detector is close. However, the phase function of the scattering medium contains the basic information of the medium morphology, and the non-diffused light has a significant impact on the reflectivity when the distance between the light source and the detector is smaller than a single transmission step. Therefore, the most important step in H...

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Abstract

The invention provides a rapid non-destructive tissue biopsy method and a technique based on a spatial frequency domain-modulated large area resolution microstructure. The method comprises the steps of 1, controlling a light source to output a plurality of spatially modulated light stripe patterns of different frequencies onto a tissue sample; 2, repeatedly collecting the reflective light intensity scattered by the tissue sample by means of a CCD; 3, analyzing and processing the collected data of the reflective light intensity; 4, demodulating the data into an AC component, a DC component and a modulation transfer function through the standard three-phase shift method, the SSMD demodulation method or the like, wherein the AC component and the DC component are different in frequency; 5, obtaining a scattering structure coefficient SSI. Based on the high-spatial-frequency SFDI modulation, not only an absorption coefficient and a scattering coefficient can be obtained, but also the phase function of the scattered light and the scattering structure coefficient SSI can be obtained. The high-spatial-frequency SFDI has important application value in the field of the large-area histological diagnosis. Based on the high-spatial-frequency SFDI, large-area tissue optical properties and the distribution diagram of scattering characteristics can be quantitatively obtained for the objective diagnosis of biological tissues.

Description

technical field [0001] The invention relates to a rapid nondestructive tissue biopsy method and technology based on spatial frequency domain modulation and large-area analytical microstructure. Background technique [0002] Light scattering through tissue can be used to diagnose tissue and has been used extensively in biomedicine. Among many different imaging methods, spatial frequency domain imaging (SFDI) has attracted great attention in a wide range of fields as a microstructure imaging method. SFDI can be used on a large scale to quantify the photonic properties of turbid media. In particular, high spatial frequency domain imaging HSFDI can improve the imaging resolution and quantitatively extract the phase function of light scattering. The problem with HSFDI is that it lacks a suitable model that can describe the light reflection coefficient in high spatial frequency analysis. In addition, conventional SFDI structures cannot achieve the accuracy and high resolution re...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/17
CPCG01N21/17G01N2021/177
Inventor 徐敏曾碧新林维豪曹自立
Owner WENZHOU MEDICAL UNIV
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