Preparation method of pH-sensitive type drug microspheres and pH-sensitive type drug microspheres prepared by preparation method

A drug and sensitive technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of unfavorable human health, prone to sudden release phenomenon, unstable hydrogel, etc., and achieve a wide range of application prospects and advantages, process conditions Ease of control, product purification and the effect of reduced processing steps
CN105963260AActive Publication Date: 2016-09-28BEIJING FORESTRY UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING FORESTRY UNIVERSITY
Publication Date
2016-09-28

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Abstract

The invention relates to a method for preparing sodium alginate (SA) / hydroxypropyl methylcellulose (HPMC) / bentonite pH-sensitive type drug microspheres. The method includes: sodium alginate and hydroxypropyl methylcellulose are polymerized for modification and then combined with diclofenac to prepare the pH-sensitive type drug microspheres. The pH-sensitive type drug microspheres prepared by the method have the advantages that the pH-sensitive type drug microspheres are good in spheronization and have evident selectivity to drug release media, the accumulation release amount of the pH-sensitive type drug microspheres is less than 1% especially in an acid environment, and the pH-sensitive type drug microspheres can protect drugs for treating intestinal diseases from being absorbed by the stomach or destroyed by gastric enzyme, prolong curative effect and increase drug stability and has promising application prospect and advantages in fields of pharmaceutical engineering and bio-based materials.
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Description

technical field

[0001] The invention relates to the field of preparation of medical materials, in particular to a method for preparing sodium alginate (SA) / hydroxypropyl methylcellulose (HPMC) / bentonite pH-sensitive drug sustained-release microspheres and preparation by the method pH-sensitive drug microspheres. Background technique

[0002] With the development of the pharmaceutical industry, natural compounds have attracted more and more attention due to their good biocompatibility and biodegradability, and are used in various fields of medical and health products and food additives. In the development process of the pharmaceutical industry, the research and development of new pharmaceutical excipients and the application of natural polymers in prescription design are a very important field. The development of pharmaceutical excipients plays a key role in the development of the entire formulation technology. At the same time, due to the continuous improvement of clinical...

Claims

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