Preparation method of pH-sensitive type drug microspheres and pH-sensitive type drug microspheres prepared by preparation method

A drug and sensitive technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of unfavorable human health, prone to sudden release phenomenon, unstable hydrogel, etc., and achieve a wide range of application prospects and advantages, process conditions Ease of control, product purification and the effect of reduced processing steps

Active Publication Date: 2016-09-28
BEIJING FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of hydrogel is fast and convenient, the hydrogel formed by ionic bond cross-linking is unstable in acidic environment and buffer solution, and it is prone to burst release phenomenon when used as a drug carrier, and the hydrophilicity of sodium alginate itself is Extremely strong, also an important reason for drug burst release
Drug microspheres in the prior art also often contain heavy metal ions, such as Pb 2+ 、Cd 2+ 、Cu 2+ etc., which are detrimental to human health

Method used

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  • Preparation method of pH-sensitive type drug microspheres and pH-sensitive type drug microspheres prepared by preparation method
  • Preparation method of pH-sensitive type drug microspheres and pH-sensitive type drug microspheres prepared by preparation method
  • Preparation method of pH-sensitive type drug microspheres and pH-sensitive type drug microspheres prepared by preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] 1. Preparation of sodium alginate / hydroxypropyl methylcellulose solution

[0061] Dissolve 2g of powdered sodium alginate in 250ml of distilled water, use a magnetic stirrer at room temperature and normal pressure, and perform stirring treatment. After complete dissolution, add 1g of hydroxypropyl methylcellulose to the above solution and continue stirring. Until it is completely dissolved, a transparent and viscous mixed solution is obtained, wherein the stirring time is 6 h and the stirring speed is 500 rpm / min.

[0062] 2. Chemical modification

[0063] Adjust the pH value of the above mixed solution to 3 with sulfuric acid with a mass percentage of 95%-98% and a concentration of 18.4mol / L, then place the beaker in a constant temperature water bath, and stir with a magnetic stirrer under normal pressure to carry out The chemical modification treatment of sodium alginate, wherein the modification treatment temperature is 40 ° C, the stirring speed is 500 rpm / min, the...

Embodiment 2

[0069] Except that the consumption of sodium alginate is 1.5 g and the consumption of hydroxypropyl methyl cellulose is 1.5 g, other conditions and operations are the same as in Example 1.

Embodiment 3

[0071] Except that the consumption of sodium alginate is 1 g and the consumption of hydroxypropyl methylcellulose is 2 g, other conditions and operations are the same as in Example 1.

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Abstract

The invention relates to a method for preparing sodium alginate (SA) / hydroxypropyl methylcellulose (HPMC) / bentonite pH-sensitive type drug microspheres. The method includes: sodium alginate and hydroxypropyl methylcellulose are polymerized for modification and then combined with diclofenac to prepare the pH-sensitive type drug microspheres. The pH-sensitive type drug microspheres prepared by the method have the advantages that the pH-sensitive type drug microspheres are good in spheronization and have evident selectivity to drug release media, the accumulation release amount of the pH-sensitive type drug microspheres is less than 1% especially in an acid environment, and the pH-sensitive type drug microspheres can protect drugs for treating intestinal diseases from being absorbed by the stomach or destroyed by gastric enzyme, prolong curative effect and increase drug stability and has promising application prospect and advantages in fields of pharmaceutical engineering and bio-based materials.

Description

technical field [0001] The invention relates to the field of preparation of medical materials, in particular to a method for preparing sodium alginate (SA) / hydroxypropyl methylcellulose (HPMC) / bentonite pH-sensitive drug sustained-release microspheres and preparation by the method pH-sensitive drug microspheres. Background technique [0002] With the development of the pharmaceutical industry, natural compounds have attracted more and more attention due to their good biocompatibility and biodegradability, and are used in various fields of medical and health products and food additives. In the development process of the pharmaceutical industry, the research and development of new pharmaceutical excipients and the application of natural polymers in prescription design are a very important field. The development of pharmaceutical excipients plays a key role in the development of the entire formulation technology. At the same time, due to the continuous improvement of clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/38A61K47/02A61K31/196A61P19/02A61P29/00
CPCA61K9/0002A61K9/1611A61K9/1652A61K31/196
Inventor 张学铭闫中亚逄锦慧吴苗李因亮刘昕
Owner BEIJING FORESTRY UNIVERSITY
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