A dual antitumor polypeptide based on the EPS8-SH3 domain

An eps8-sh3, anti-tumor technology, applied in the field of preparing anti-tumor drugs, can solve the problems of low inhibition rate and unsatisfactory tumor cell proliferation inhibition effect.
CN105968181BInactive Publication Date: 2019-05-03SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2019-05-03
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention relates to an Eps8-SH3 structural domain-based dual antitumor polypeptide. The polypeptide has an amino acid sequence of Lys-Tyr-Ala-Lys-Ser-Lys-Tyr-Asp-Phe (SEQ ID No: 1). The dual antitumor polypeptide can induce cytotoxic T cells, effectively kill HLA-A*2402 positive and Eps8 positive tumors, directly inhibit HLA-A*2402 positive and Eps8 positive tumor cell proliferation and be used for preparation of dual antitumor drugs.
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Description

technical field

[0001] The invention relates to the field of organic chemistry, in particular to a polypeptide from mammals, which has anti-tumor activity and is suitable for preparing anti-tumor drugs. Background technique

[0002] Peptide drugs have very important development value in clinical application. Some peptide drugs have the effect of promoting the immune function of the body, which are called peptide vaccines. The identification of novel tumor antigens that induce strong and specific antitumor immune responses warrants the development and clinical application of peptide vaccines against various types of tumors (Reche P, et al. J Immunol Res2015; 2015:349049; Jazirehi AR, et al .Cancer Res 2011; 71(4):1406-1417; Andersen RS, et al. Cancer Immunol Immunother 2011; 60(2):227-234; Gritzapis AD, et al. Cancer Res 2010; 70(7):2686-2696 ; Klepin HD, et al. Oncologist 2009; 14(3):222-232.). So far, there have been many clinical trials using tumor-associated antigen-de...

Claims

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