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A polymer and material layer technology, applied in prostheses, dressings, drug delivery, etc., can solve problems such as limitations

Active Publication Date: 2020-03-10
OXFORD UNIV INNOVATION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many authors have attempted to improve the material itself through better fiber alignment, or post-treatments such as crosslinking and bonding, but those techniques provide limited mechanical improvements that are often below the desired range

Method used

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Examples

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Embodiment 1

[0124] Example 1: Manufacturing of multi-layer patch for rotator cuff repair: non-destructive combination of woven fabric and electrospun fabric

[0125] The purpose of this research is to produce rotator cuff repair patches with excellent mechanical and biological properties. This goal is achieved by combining a woven fabric (which will provide mechanical support) with a non-woven electrospinning assembly (which will provide clues and guidance to natural cells by exhibiting a fine, nanoscale morphology).

[0126] Introduction

[0127] In this example, the use of new, biocompatible and non-destructive bonding methods for multilayer electrospun materials and fabrics is explored. This embodiment first discusses the mechanical and in vitro properties of a patch composed of a woven fabric connected to a non-woven electrospinning assembly. The non-woven component is a oriented PDO electrospinning scaffold designed to provide excellent biological properties. The braided component is a p...

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Abstract

A scaffold for tissue repair or wound dressing, the scaffold comprising: a material layer; a polymer fiber layer; and an adhesive assembly between the material layer and the polymer fiber layer, wherein the adhesive assembly includes an Materials with a lower melting temperature (Tm) than the fiber layer.

Description

Technical field [0001] The present invention relates to a biodegradable scaffold for tissue repair, a method for preparing such scaffolds and their uses. Background technique [0002] Tendon inflammation and age-related degeneration cause shoulder pain, which affects more than 30% of the population. When conservative treatment fails, rotator cuff surgery is more and more common, and its rate has increased by more than 500% in the UK since 2001. However, clinical and imaging studies have questioned the effectiveness of rotator cuff repair surgery, indicating that the repaired structure fails in 20-90% of cases. In order to deal with this problem, a new repair strategy has been proposed. Among them, since the degradable synthetic stents can combine well-regulated mechanical properties, biological additives, and minimize the risk of infection through complete absorption in time, their use has shown high potential. However, these stents are still limited in terms of biocompatibili...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/56
CPCA61L27/18A61L27/56A61L2400/12C08L67/04A61F13/02A61L27/38A61L27/58A61L2300/64
Inventor 奥斯纳特·哈基米皮埃尔-亚历克西·穆蒂纳西姆·扎尔加·巴博尔达什蒂安德鲁·卡尔
Owner OXFORD UNIV INNOVATION LTD