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Systems and methods for obtaining immunoglobulin from blood

An immunoglobulin and blood technology, applied in the direction of immunoglobulin, chemical instruments and methods, blood circulation treatment, etc., can solve problems such as cost increase and delayed infusion

Inactive Publication Date: 2016-10-12
BAXTER INT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methods of obtaining immunoglobulins from donors require several processing steps in one or more facilities that are often not located at the same location as the donor and recipient, delaying infusions and leading to increased costs

Method used

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  • Systems and methods for obtaining immunoglobulin from blood
  • Systems and methods for obtaining immunoglobulin from blood
  • Systems and methods for obtaining immunoglobulin from blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1: Infusion of Immunoglobulins from Donor Plasma to Recipients

[0116] Immunoglobulins can be obtained, including isolated, from donors and used for infusion into recipients.

[0117] In an exemplary method, blood is first obtained from a recipient by any method known in the art. The plasma is then separated from the donor blood and sterilized to inactivate the virus. Next, the sterilized plasma is contacted with the protein A matrix. Alternatively, alternating columns can be used to capture IgG. The column can be washed and the eluted IgG goes to another column (see e.g. figure 2 ). Alternatively, hollow fiber membranes with protein A or another immunoglobulin capture ligand can be used (see e.g. image 3 with 4 ). Optionally, IgG-poor plasma and blood can be returned to the donor. Captured IgG can be eluted from the matrix during blood donation or isolated from donated blood. Elution can be scheduled separately from the blood donation or simultaneou...

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PUM

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Abstract

The present disclosure relates generally to systems for obtaining a pharmaceutically acceptable immunoglobulin from blood of a donor comprising a first conduit configured to convey blood from the donor to a substrate, wherein said blood includes at least one first component and at least one second component, said first component of the blood including immunoglobulin, and wherein said substrate is adapted to bind immunoglobulin; and a second conduit configured to convey at least a portion of the second component of the blood from the first conduit to the donor.

Description

[0001] This application has an international filing date of December 18, 2009, international application number PCT / US2009 / 068753 entered the Chinese national phase on June 20, 2011, application number 200980151670.0, and the title of the invention "System and method for obtaining immunoglobulin from blood " divisional application. field of invention [0002] The present disclosure generally relates to systems and methods for obtaining and / or isolating blood components, including, for example, immunoglobulins (eg, IgG). Immunoglobulin isolated from the donor can be delivered (eg, infused directly) to the recipient. The present disclosure also relates generally to methods of treating diseases or conditions, including those associated with immunodeficiency, via administration to a recipient of immunoglobulins isolated from donors by the systems of the present disclosure. Background technique [0003] Immunoglobulins (also known as antibodies) are specific antigen-binding prot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34A61M1/38
CPCA61M1/3486A61M1/3472A61M1/38A61M2202/0419A61P25/28A61P37/04A61M2202/0057A61M1/0213A61M1/0218A61K39/395A61M1/0259A61M1/385A61M25/01C07K16/42A61M1/85
Inventor 闵京允拉里·贝克斯弗朗西斯科·M·罗萨三世肖恩·F·拜尔斯托辛杜·拉马钱德兰沙伦·波克罗平斯基
Owner BAXTER INT INC