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A method for measuring the concentration of flutrimazole in blood plasma

A flutripmazole and plasma technology is applied in the field of measuring the concentration of flutramazole in plasma, and achieves the effects of simple operation, high sensitivity and stable baseline.

Inactive Publication Date: 2018-03-30
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are no literature reports on the in vivo assay of flutrimazole

Method used

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  • A method for measuring the concentration of flutrimazole in blood plasma
  • A method for measuring the concentration of flutrimazole in blood plasma
  • A method for measuring the concentration of flutrimazole in blood plasma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] Example: Determination of Flutrimazole Concentration in Human Plasma

[0025] 1. Experimental materials and instruments

[0026] Flutrimazole: provided by Beijing Sihuan Kebao Pharmaceutical Co., Ltd., batch number 20081030, content: 100%; Simvastatin (internal standard): purchased from China Institute for the Control of Pharmaceutical and Biological Products, 1006016-200502; Test water: super Pure water; methanol: chromatographically pure (Merck Company).

[0027] Waters Quattro Micro LC\MS\MS coupled instrument (Waters, USA), chromatographic workstation: Masslynx 4.1; Mettler-Toledo AE240 electronic balance (Shanghai Mettler-Toledo Co., Ltd.); BiofugePrimoR refrigerated high-speed centrifuge ( Heraeus, Germany); 80-2CENTRIFUGE centrifuge (Shanghai Pudong Physical Optical Instrument Factory); Millipore Drict-Q5 ultrapure water machine (Millipore, France); WH-2 micro-vortex mixer (Shanghai Huxi Analytical Instrument Factory).

[0028] 2. Liquid conditions

[0029] 1....

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Abstract

The invention discloses a method for measuring the concentration of flutrimazole in blood plasma. The liquid-mass spectrometry system is used for the measurement. The sample to be tested is firstly taken, and a certain amount of organic solvent liquid-liquid extraction agent is added for liquid-liquid extraction. After pretreatment, the Separation by chromatographic column and detection by a mass spectrometer, the method of the invention is fast, accurate, high in sensitivity and easy to operate, and is suitable for determining the concentration of flutrimazole in blood plasma.

Description

technical field [0001] The invention belongs to the technical field of biological detection, in particular to a method for measuring the concentration of flutrimazole in blood plasma. Background technique [0002] Flutrimazole is an imidazole topical antifungal ointment. Like other imidazole derivatives, it inhibits the activity of lanosterol-14-demethylase, interferes with the synthesis of ergosterol, and causes the denaturation of fungal cell membranes, thereby achieving antifungal effects. It is a new drug source with good development prospects compound. Its structural formula is as follows: [0003] [0004] There are no reports in the literature on the in vivo assay of flutrimazole. The invention establishes a method for measuring flutrimazole in human body, and conducts exploratory research on drug metabolism of flutrimazole by the method. Contents of the invention [0005] The technical problem to be solved by the present invention is to establish an accurate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027
Inventor 刘史佳张农山戴国梁居文政储继红李长印许美娟吴婷张军冯丽雯
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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