A method for measuring the concentration of flutrimazole in blood plasma

A flutripmazole and plasma technology is applied in the field of measuring the concentration of flutramazole in plasma, and achieves the effects of simple operation, high sensitivity and stable baseline.
CN106018581BInactive Publication Date: 2018-03-30JIANGSU PROVINCIAL HOSPITAL OF TCM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU PROVINCIAL HOSPITAL OF TCM
Publication Date
2018-03-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for measuring the concentration of flutrimazole in blood plasma. The liquid-mass spectrometry system is used for the measurement. The sample to be tested is firstly taken, and a certain amount of organic solvent liquid-liquid extraction agent is added for liquid-liquid extraction. After pretreatment, the Separation by chromatographic column and detection by a mass spectrometer, the method of the invention is fast, accurate, high in sensitivity and easy to operate, and is suitable for determining the concentration of flutrimazole in blood plasma.
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Description

technical field

[0001] The invention belongs to the technical field of biological detection, in particular to a method for measuring the concentration of flutrimazole in blood plasma. Background technique

[0002] Flutrimazole is an imidazole topical antifungal ointment. Like other imidazole derivatives, it inhibits the activity of lanosterol-14-demethylase, interferes with the synthesis of ergosterol, and causes the denaturation of fungal cell membranes, thereby achieving antifungal effects. It is a new drug source with good development prospects compound. Its structural formula is as follows:

[0003]

[0004] There are no reports in the literature on the in vivo assay of flutrimazole. The invention establishes a method for measuring flutrimazole in human body, and conducts exploratory research on drug metabolism of flutrimazole by the method. Contents of the invention

[0005] The technical problem to be solved by the present invention is to establish an accurate...

Claims

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