Application and method of α-chymotrypsin in synthesizing bisindolyl-indolin-2-one compounds

A technology of chymotrypsin and ketone compounds, applied in the field of chemistry, to achieve the effects of easy operation, rich research and high yield in the catalytic process

Active Publication Date: 2019-10-22
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Interestingly, certain bisindolyl-indolin-2-one derivatives have been reported to act strongly on a range of tumor cells but not on normal cells

Method used

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  • Application and method of α-chymotrypsin in synthesizing bisindolyl-indolin-2-one compounds
  • Application and method of α-chymotrypsin in synthesizing bisindolyl-indolin-2-one compounds
  • Application and method of α-chymotrypsin in synthesizing bisindolyl-indolin-2-one compounds

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Embodiment Construction

[0029] The following will describe in detail in combination with preferred embodiments. For the experimental methods that do not specify specific conditions in the examples, usually follow the conventional conditions or the conditions suggested by the manufacturer.

[0030] 1. Screening of solvents for the synthesis of bisindolyl-indolin-2-one by Friedel-Crafts reaction catalyzed by α-chymotrypsin

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Abstract

The invention discloses application of alpha-chymotrypsin catalyzed friedel-crafts reaction in synthesizing a bis(indolyl)-indoline-2-ketone compound and a method thereof. A general formula 1 and a general formula 2 can produce the bis(indolyl)-indoline-2-ketone compound in methanol or ethanol solution under catalysis of the alpha-chymotrypsin. The catalytic process of the method is simple and easy in operation, the highest yield can reach 97%, excellent substrate adaptability is exhibited, research on multifunctionality of enzyme is enriched, and also an efficient synthesis approach for synthesizing the bis(indolyl)-indoline-2-ketone compound is provided.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to the application of the Friedel-Crafts reaction catalyzed by α-chymotrypsin in the synthesis of bisindolyl-indolin-2-ketone compounds, and also relates to the preparation of bisindolyl-indoline Method for indol-2-ones. Background technique [0002] Since indole was discovered in 1866 because of its special structural characteristics, it has become a research hotspot in many fields including medicine, spices, agricultural chemicals, pigments and material science. These works clearly show the role of indole in organic synthesis. occupy an important position. [0003] Bisindole structure exists in many drugs. Such derivatives have been proven to have a wide range of biological activities, such as anti-plasmodium, anti-virus, anti-bacterial, anti-tumor, anti-convulsant, treatment of Parkinson's disease and effective inhibitor of SARS coronavirus 3CL protease. Among them, bisindolyl-indolin-2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P17/16
Inventor 官智薛靖文
Owner SOUTHWEST UNIV
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