Hybrid network gene screening method based on gene expression data

A gene expression, hybrid network technology, applied in genomics, electrical digital data processing, special data processing applications, etc., can solve the problem of low accuracy of gene screening

Inactive Publication Date: 2016-10-26
HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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Problems solved by technology

[0005] The purpose of the present invention is to provide a hybrid network gene screening method based

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  • Hybrid network gene screening method based on gene expression data
  • Hybrid network gene screening method based on gene expression data
  • Hybrid network gene screening method based on gene expression data

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specific Embodiment 1

[0052] Specific examples are as figure 1 .2.3. Shown.

[0053] figure 1 A schematic diagram of a hybrid network provided by the present invention is shown. A hybrid network gene screening method based on gene expression data, comprising the following steps:

[0054] A. Construction of a gene interaction network; the gene interaction network includes protein G formed after transcription of the gene to be tested and protein Gi formed after transcription of N genes closely related to the gene to be tested, wherein i=1,2 ... n; the gene interaction network is in figure 1 The uppermost end of the network is composed of G and Gi. In this network, both Gi and G are correlated by default, and genes without correlation have been excluded.

[0055] B. Build a disease similarity network; the disease similarity network includes the disease D to be tested and the disease Di highly similar to the D, where i=1, 2...n, and use the matrix Dsim[D i ,D j ] represents the similarity between...

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Abstract

The invention relates to the field of genetic diagnosis, and particularly relates to a hybrid network gene screening method based on gene expression data. According to the scheme, by introducing the gene expression data, a hybrid network gene screening method model based on the gene expression data is designed, and specific steps how to construct different networks by the gene expression data are given out; and the gene expression data is utilized to carry out more detailed and deep quantization on diseases and genes and a mutual relationship network between the genes so as to reinforce comprehensive capacity of the entire hybrid model on the aspect of disease gene screening.

Description

technical field [0001] The invention relates to the field of gene diagnosis, in particular to a hybrid network gene screening method based on gene expression data. Background technique [0002] Disease genes refer to genes that are closely related to the occurrence and development of certain complex diseases, and these genes directly or indirectly determine whether humans will suffer from certain diseases. Therefore, the study of these disease genes is a challenging issue related to human health and medical treatment. The first thing to do before studying disease genes is to find and discover these genes, and the screening of disease genes has long been a major challenge in human genome research. [0003] There are many existing disease gene screening technologies such as application number 201010170331.1, and the invention patent titled "Undirected Network Screening Method for Key Genes of Human Polygenic Diseases" discloses an undirected network screening method for key g...

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Application Information

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IPC IPC(8): G06F19/18
CPCG16B20/00
Inventor 徐勇吴帅
Owner HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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