A kind of detection method of cortex moutan granules

A detection method and a technique for Cortex Moutan, applied in the field of Cortex Moutan granules and traditional Chinese medicine preparations containing Cortex Peony granules, can solve the problems of inability to analyze multiple varieties and batches of samples in real time, physical injury of inspectors, lag in information feedback, etc. The process parameters are easy to control, the accuracy is high, and the process parameters are stable.

Active Publication Date: 2017-08-25
GUANGDONG YIFANG PHARMA
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  • Claims
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AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture and ethanol extracts in Moutan Cortex granules requires several hours with reference to the Pharmacopoeia, and the operation is more complicated.
The main chemical component of Moutan cortex granules is paeoniflorin, which is used as a quality control index. The traditional method uses high performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment. Due to the physical injury of the staff, the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of detection method of cortex moutan granules
  • A kind of detection method of cortex moutan granules
  • A kind of detection method of cortex moutan granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Moutan cortex granules: Take the decoction pieces of Moutan cortex, add 3 times the amount of water, heat and distill for 3 hours, collect the distillate, let it stand for more than 24 hours, and filter after the crystallization is relatively complete to obtain the volatile components of Moutan cortex, add two Silica adsorption, stirring evenly, to obtain silica adsorbate, for later use; filter the distilled aqueous solution to obtain the distilled extract of Moutan cortex, for later use; decoct the dregs with water for 3 times, adding 8 times the amount of water each time, Heat and decoct for 1 hour, combine the extracts, concentrate the filtrate to a clear paste with a relative density of 1.08, and filter it with a 350-mesh sieve while it is hot; at an inlet air temperature of 185°C, a feed pump speed of 500 rpm, and an outlet air temperature of 90°C , Spray drying under the condition of air supply temperature of 40°C to obtain spray dry powder, mix the ...

Embodiment 2

[0036] Preparation of traditional Chinese medicine preparations containing Moutan cortex granules: Take Moutan cortex decoction pieces, add 3 times the amount of water, heat and distill for 3 hours, collect the distillate, let stand for more than 24 hours, and filter after the crystallization is relatively complete to obtain the volatile ingredients, add silica for adsorption, stir evenly to obtain silica adsorbate, and set aside; filter the distilled aqueous solution to obtain the distilled extract of Moutan cortex, and set aside; decoct the dregs with water for 3 times, each time adding 8 Double the amount of water, heat and decoct for 1 hour, combine the extracts, concentrate the filtrate to a clear paste with a relative density of 1.08, and filter it with a 350-mesh sieve while it is hot; The air temperature is 90°C, and the air supply temperature is 40°C for spray drying to obtain spray dry powder. Mix the spray dry powder with silica adsorbate evenly. The hole diameter of...

Embodiment 3

[0038] A method for rapidly detecting the moisture content of cortex moutan granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0039] a. Take Moutan bark granule samples, a total of 70 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000-12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 70 batches of cortex moutan particles shown;

[0040] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was determined by the drying method. About 2 g of the cortex moutan cortex that was ground into fine powder was sprea...

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Abstract

The invention discloses moutan bark granules and a traditional Chinese medicine preparation thereof. The moutan bark granules are prepared through a method including the following steps that moutan bark decoction pieces are taken to be heated and distilled, distillate is collected, standing is carried out, filtering is carried out after complete crystallization separation, moutan bark volatile components are obtained, silicon dioxide is added for adsorption, and silicon dioxide adsorbate is obtained for use; an aqueous solution obtained after distillation is filtered, and moutan bark post-distillation extract liquor is obtained for use; water is added into residues for decoration, extract liquor is mixed, filter liquor is concentrated, and filtration is carried out while the temperature is high; clear paste is taken to be subjected to spray drying, and spray-dried powder is obtained; the spray-dried powder and the silicon dioxide adsorbate are mixed evenly, dry granulation is carried out, and the moutan bark granules with the granularity ranging from 16 meshes to 40 meshes are obtained. The preparation process of the moutan bark granules is simple, process parameters are easy to control, and a scientific and fast detection method with high operability is provided.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a kind of moutan cortex granule and a traditional Chinese medicine preparation containing the moutan cortex granule. Background technique [0002] Cortex Moutan is the dry root bark of Paeonia suffruticosa Andr., a plant of the Ranunculaceae family. It is bitter, pungent, and slightly cold, and has the effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/3563G01N21/359A61K36/71A61K36/65A61K9/16A61K9/20
CPCA61K9/16A61K9/205A61K36/65A61K36/71A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359
Inventor 陈向东朱德全霍慧灵刘丽萍王闽予谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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