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Pericarpium citri reticulatae granules and traditional Chinese medicine preparation thereof

A technology of tangerine peel and granules, which is applied in the field of tangerine peel granules and their traditional Chinese medicine preparations, can solve the problems of inspectors' physical injury, reagent consumption, quality control, etc., and achieve the effects of shortening detection time, reducing workload, and reducing errors.

Active Publication Date: 2016-11-09
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional method of determining the moisture in tangerine peel formula granules requires several hours by referring to the pharmacopoeia, and the operation is more complicated.
The main chemical component of tangerine peel formula granules is hesperidin. As a quality control index, traditional methods use high-performance liquid chromatography, etc., which often require complicated pretreatment of samples, consume a large amount of reagents, cause great environmental pollution and are harmful to inspection. The staff suffered physical injuries, and the information feedback lagged behind, unable to meet the needs of real-time analysis of multi-variety and multi-batch samples in the mass production process of formula granule enterprises

Method used

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  • Pericarpium citri reticulatae granules and traditional Chinese medicine preparation thereof
  • Pericarpium citri reticulatae granules and traditional Chinese medicine preparation thereof
  • Pericarpium citri reticulatae granules and traditional Chinese medicine preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Preparation of tangerine peel granules: take tangerine peel decoction pieces, add 3 times the amount of water, heat and distill for 2 hours, collect volatile oil and aromatic water, use β-cyclodextrin inclusion compound to obtain β-cyclodextrin inclusion complex, filter the liquid, Standby; decoct the dregs with water twice, each time 10 times the amount of water, heat and decoct for 1.5 hours for the first time, and decoct for 0.5 hours for the second time, and combine the medicinal liquid; the filtrate is concentrated to a clear paste with a relative density of 1.08, Filter while hot with a 350-mesh sieve; spray-dry under the conditions of an inlet air temperature of 180°C, a material pump speed of 500 rpm, an outlet air temperature of 85°C, and an air supply temperature of 45°C to obtain a spray-dried powder; mix the spray-dried powder with The β-cyclodextrin inclusion complex was mixed evenly, and dry granulated under the conditions of punching plate aperture 1.50mm,...

Embodiment 2

[0034] Preparation of traditional Chinese medicine preparations containing tangerine peel granules: take tangerine peel decoction pieces, add 3 times the amount of water, heat and distill for 2 hours, collect volatile oil and aromatic water, and include β-cyclodextrin to obtain β-cyclodextrin inclusion compound. Filtrate the liquid and set aside; decoct the dregs with water twice, each time 10 times the amount of water, heat and decoct for 1.5 hours for the first time, and decoct for 0.5 hours for the second time, and combine the liquid medicine; the filtrate is concentrated to a relative density of 1.08 The clear paste is filtered with a 350-mesh sieve while it is still hot; it is spray-dried under the conditions of an air inlet temperature of 180°C, a material pump speed of 500 rpm, an outlet air temperature of 85°C, and an air delivery temperature of 45°C to obtain a spray-dried powder; Mix the spray-dried powder and β-cyclodextrin inclusion compound evenly, dry granulate un...

Embodiment 3

[0036] A method for rapidly detecting the moisture content of tangerine peel granules based on near-infrared spectroscopy, specifically comprising the steps of:

[0037] a. Take tangerine peel granule samples, a total of 118 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 118 batches of orange peel particles shown;

[0038] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was measured by drying method, and about 2 g of tangerine peel particles ground into fine powder were taken, spread fla...

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Abstract

The invention discloses pericarpium citri reticulatae granules and a traditional Chinese medicine preparation thereof. The pericarpium citri reticulatae granules are prepared by the following steps: taking pericarpium citri reticulatae decoction pieces, adding 2-5 times amount of water, performing heating and distillation for 1-3 hours, collecting volatile oil and aromatic water, subjecting volatile oil and aromatic water to inclusion to obtain beta-cyclodextrin inclusion compound, and filtering decoction for standby use; adding water into decoction dregs for decocting for 1-2 times in the proportion of water to decoction dregs being 1:5-10 each time, heating and decocting for 1-2 hours, and combining decoctions; concentrating filtrate to clear paste with relative density being 1.02-1.12, and filtering the clear paste with a 250-350-mesh sieve while hot; taking the clear paste for spray drying to obtain spray-dried powder; uniformly mixing the beta-cyclodextrin inclusion with the spray-dried powder, and performing dry granulating to obtain the 16-40-mesh pericarpium citri reticulatae granules. The pericarpium citri reticulatae granule preparation process is simple, process parameters are easy to control, and the method is scientific, quick and strong in operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a tangerine peel granule and a traditional Chinese medicine preparation thereof. Background technique [0002] Tangerine peel is the dried and mature pericarp of Citrus reticulata Blanco and its cultivars of the Rutaceae plant. It is bitter, pungent, and warm, and returns to the lung and spleen meridian. Under the existing conventional storage conditions, the smell of medicinal materials is easy to lose, and it is not suitable for long-term storage, and the storage conditions are relatively strict. And the appearance of traditional Chinese medicine granule has solved the storage problem of this class medicinal material of tangerine peel. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/16A61K47/40G01N21/359G01N21/3563
CPCA61K9/1652A61K36/752G01N21/3563G01N21/359
Inventor 朱德全刘丽萍黄小丹王闽予陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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