Competitive combined Nav1.7/KIF5b protein binding site polypeptide structure
A protein binding site and competitive binding technology, applied in the field of competitively binding Nav1.7/KIF5b protein binding site polypeptide structure, can solve problems such as expression interference and inability to completely relieve pain, reduce abnormal upregulation, and relieve neuropathy rational pain effect
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[0031] Embodiment of the present invention is described below, and embodiment does not constitute limitation of the present invention:
[0032] Published 6 groups competitively binding Na v 1.7 / KIF5b protein binding site polypeptide structural sequence is as follows:
[0033] , ILVHSLFSMLIMCTILTNCIFMTM
[0034] , NVEYTFTGIYTFESLIKILA
[0035] , PWNWLDFVVIVFAYLTEFV
[0036] , ALRTFRVLRALKTISVIPGL
[0037] , VMILTVFCLSVFALIGLQLFMGNL
[0038] , MIFFVVVIFLGSFYLINLILAVVAMA
[0039] The modified peptide sequence can compete for the binding of Na v 1.7 / KIF5b protein binding site, highly selective reduction of Na v 1.7 Transport from cytoplasm to membrane, thereby reducing Na on DRG membrane v The abnormal up-regulation of 1.7 may alleviate the occurrence of neuropathic pain as a result.
[0040]
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