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Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists

An anti-angiogenesis and agent technology, applied in biochemical equipment and methods, anti-animal/human immunoglobulin, drug combination, etc., can solve problems such as incomplete response to bevacizumab

Inactive Publication Date: 2016-11-16
F HOFFMANN LA ROCHE & CO AG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as in previous studies of angiogenesis inhibitors, some of these Phase III studies have shown that a subset of patients experience incomplete response to the addition of bevacizumab to their chemotherapy regimen

Method used

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  • Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
  • Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
  • Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists

Examples

Experimental program
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Effect test

Embodiment 1

[0577] Example 1: Combination anti-VEGF+anti-OX40 treatment exhibits greater efficacy than single agent treatment

[0578] Combining different modalities of cancer therapy can lead to beneficial effects on tumor growth. As described below, anti-VEGF treatment resulted in decreased tumor growth compared to anti-GP120 (control) treated mice. Anti-OX40 treatment alone exhibited little activity. Surprisingly, anti-OX40 treatment in combination with anti-VEGF treatment exhibited superior tumor growth inhibition compared to single agent administration or anti-GP120 treatment despite having little antitumor activity on its own. Without wishing to be bound by theory, it is hypothesized that the synergistic increase in activity observed for combined anti-VEGF + anti-OX40 treatment may be due to increased intratumoral dendritic cell activation induced by anti-VEGF treatment.

[0579] The results described herein suggest that sequential anti-OX40 treatment with anti-VEGF administration...

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Abstract

The disclosure provides compositions and methods for treating cancers. The method comprises administering an anti-angiogenesis agent and an OX40 binding agonist.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Application Serial No. 61 / 973,193, filed March 31, 2014; U.S. Provisional Application Serial No. 61 / 989,448, filed May 6, 2014; Serial No. 62, filed October 31, 2014 Priority of U.S. Provisional Application Serial No. 62 / 080,171 filed November 14, 2014; and U.S. Provisional Application Serial No. 62 / 113,345 filed February 6, 2015, by reference to Each of them is included in this article in its entirety. [0003] sequence listing [0004] The content of the following submission on ASCII text file is incorporated herein by reference in its entirety: Sequence Listing in Computer Readable Format (CRF) (File Name: 146392031540SEQLIST.txt, Date of Record: March 26, 2015, Size: 188KB). field of invention [0005] The present invention relates to methods of treating cancer by administering anti-angiogenic agents and OX40 binding agonists. Background of the invention [0006] Angiogen...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K39/395A61K48/00A61K47/48C07K16/30C07K16/22C07K16/28
CPCA61K39/3955A61K39/39558A61K45/06A61K48/00C07K16/22C07K16/2878C07K16/30C07K16/3069A61K2039/507C07K2317/75C07K2317/76C07K2317/92C07K2317/515C07K2317/51C07K2317/56C07K2317/71A61K47/6849A61P35/00A61P43/00A61K2039/505A61K47/6803C12N15/63C12N15/70C12N2800/00C12N15/79C12N5/10C12N15/64C07K16/3015C07K16/3023C07K16/303C07K16/3038C07K16/3046C07K2317/21C07K2317/24C07K2317/732
Inventor K·沃尔什P·德阿梅达杜常春J·金J·朱J·贝弗斯三世J·安德亚Y·沈
Owner F HOFFMANN LA ROCHE & CO AG
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