Fructus evodiae total alkaloids extraction method

A technology of total alkaloids and extraction method, which is applied in the field of medicine, can solve the problems of unreported bacteriostasis-related effects, long process time, and low yield, and achieve the effects of short production process, easy industrialization, and high yield

Inactive Publication Date: 2016-12-07
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current extraction methods of Evodia rutaecarpa alkaloids mainly have shortcomings such as low y

Method used

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  • Fructus evodiae total alkaloids extraction method

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Embodiment 1

[0024] Embodiment 1 A method for extracting total alkaloids of Evodia rutaecarpa, comprising the following steps:

[0025] (1) After crushing 100g of Evodia rutaecarpa into a 200-mesh coarse powder, add water to make a suspension with a concentration of 20% wt of Evodia rutaecarpa.

[0026] (2) Homogenize the suspension to obtain a homogeneous solution of Evodia rutaecarpa.

[0027] Among them: Homogenization refers to the use of a low-temperature cooling circulation system to control the temperature of the homogenization system at 0~4°C; then add clean water to the hopper of the homogenizer, start the machine, and adjust the homogenization working pressure to 300 bar and flow rate to 10 L / h , when the clear water flows to the bottom of the hopper, add the suspension into the hopper, and replenish the material in time, circulate, complete the homogenization after 1 hour, and obtain the homogeneous liquid of Evodia rutaecarpa.

[0028] (3) Filter Evodia rutaecarpa homogeneous ...

Embodiment 2

[0030] Embodiment 2 A method for extracting total alkaloids of Evodia rutaecarpa, comprising the following steps:

[0031] (1) After crushing 100 g of Evodia rutaecarpa into a 200-mesh coarse powder, add water to prepare a suspension with a concentration of 30% wt of Evodia rutaecarpa.

[0032] (2) Homogenize the suspension to obtain a homogeneous solution of Evodia rutaecarpa.

[0033] Among them: Homogenization refers to the use of low-temperature cooling circulation system to control the temperature of the homogenization system at 0~4°C; after that, add clean water into the hopper of the homogenizer, start the machine, and adjust the homogenization working pressure to 400 bar and the flow rate to 15 L / h , when the clear water flows to the bottom of the hopper, add the suspension into the hopper, and replenish the material in time, circulate, complete the homogenization after 2 hours, and obtain the homogeneous liquid of Evodia rutaecarpa.

[0034] (3) Filter the homogeneou...

Embodiment 3

[0036] Embodiment 3 A method for extracting total alkaloids of Evodia rutaecarpa, comprising the following steps:

[0037] (1) After crushing 100 g of Evodia rutaecarpa into a 300-mesh coarse powder, add water to make a suspension with a concentration of 20% wt of Evodia rutaecarpa.

[0038] (2) Homogenize the suspension to obtain a homogeneous solution of Evodia rutaecarpa.

[0039] Among them: Homogenization refers to the use of a low-temperature cooling circulation system to control the temperature of the homogenization system at 0~4°C; after that, add clean water to the hopper of the homogenizer, start the machine, and adjust the homogenization working pressure to 500 bar and the flow rate to 20 L / h , when the clear water flows to the bottom of the hopper, add the suspension into the hopper, and replenish the material in time, circulate, complete the homogenization after 3 hours, and obtain the homogeneous liquid of Evodia rutaecarpa.

[0040] (3) Filter Evodia rutaecarpa...

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Abstract

The invention relates to a fructus evodiae total alkaloids extraction method. The method comprises the follow steps of smashing fructus evodiae into coarse powder and adding water into the coarse powder to prepare suspension; homogenizing the suspension to obtain fructus evodiae homogenate; processing the fructus evodiae homogenate step by step, then adding 75% ethyl alcohol, and sealing for freezing, thus obtaining supernate; drying the supernate under reduced pressure to obtain a fructus evodiae total alkaloids extract. The method is high in extract yield, short in production flow and easy to industrialize; in addition, the extract has an obvious restraining effect on staphylococcus aureus, helicobacter polyri, pseudomonas aeruginosa, drug-resistant staphylococcus epidermidis and escherichia coli.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for extracting total alkaloids from Evodia rutaecarpa. Background technique [0002] Evodia rutaecarpa is a Rutaceae plant Evodia rutaecarpa Evodia rutaecarpa (Juss) Benth. , Shi Hu Evodia rutaecarpa (Juss). vat. officinalis (Dode) Huang Benth. , Evodia pilosa Evodia rutaecarpa (Juss) Benth. vat, bodinieri (Dode) Yellow dry near-ripe fruit, bitter in taste, warm in nature, slightly poisonous; capable of warming the middle and expelling cold, soothing the liver and relieving pain. For Jueyin headache, abdominal cold pain, vomiting and diarrhea, dysmenorrhea, hypertension and other diseases. It mainly contains a variety of chemical components such as alkaloids, volatile oils, and bitters. [0003] Studies have shown that the extracts of Evodia Evodia are mainly composed of alkaloids, volatile oils, bitters and other chemical components, and some studi...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P31/04
CPCA61K36/754A61K2236/331A61K2236/53Y02A50/30
Inventor 陈朋李素岳王宁波吴争荣
Owner LANZHOU UNIVERSITY
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