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Extraction method and application of ethyl acetate and n-butyl alcohol extracts of euonymus fortunei

A technology of ethyl pike acetate and extraction method, which is applied in the field of medicinal liquid extraction, can solve problems that have not been reported before, and achieve the effect of preventing or treating cardiovascular diseases

Inactive Publication Date: 2016-12-14
PHARMA FACTORY OF GUANGXI TRADITIONAL CHINESE MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] It can be seen from the above that although people have carried out various researches on Euonymus periwinkle, the effect of Euonymus periwinkle on protecting vascular endothelial cells has not been reported yet.

Method used

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  • Extraction method and application of ethyl acetate and n-butyl alcohol extracts of euonymus fortunei
  • Extraction method and application of ethyl acetate and n-butyl alcohol extracts of euonymus fortunei
  • Extraction method and application of ethyl acetate and n-butyl alcohol extracts of euonymus fortunei

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Euonymus radix extract preparation 1

[0022] The extraction method of Euonymus euphonium ethyl acetate and n-butanol extract comprises the steps of: taking Euonymus euphonium medicinal material, beating into fine powder, passing through a 40-mesh sieve, and for subsequent use; Ethanol, soaked 3 times, soaked for 12 hours each time; the soaking solution was filtered through a 200-mesh sieve, suction filtered, and concentrated under reduced pressure to no alcohol smell to obtain a concentrated solution; the concentrated solution was extracted with ethyl acetate and n-butanol in sequence, The extraction method is as follows: ethyl acetate and n-butanol are respectively extracted 3 times, and each time is 3 times the solvent amount of the concentrated solution according to the mass percentage. The extracts were combined, and then subjected to suction filtration, and the filtrate recovered the solvent and dried under reduced pressure to obtain the ethyl acetate...

Embodiment 2

[0023] Example two Euonymus euphratica extract preparation two

[0024] The extraction method of Euonymus euphonium ethyl acetate and n-butanol extract comprises the steps of: taking Euonymus euphonium medicinal material, grinding into fine powder, passing through 80 mesh sieves, and for subsequent use; Ethanol, soaked 3 times, soaked for 16 hours each time; the soaking solution was filtered through a 200-mesh sieve, suction filtered, and concentrated under reduced pressure to no alcohol smell to obtain a concentrated solution; the concentrated solution was extracted with ethyl acetate and n-butanol in sequence, The extraction method is as follows: ethyl acetate and n-butanol are respectively extracted 3 times, and each time is 3 times the solvent amount of the concentrated solution according to the mass percentage. The extracts were combined, and then subjected to suction filtration, and the filtrate recovered the solvent and dried under reduced pressure to obtain the ethyl a...

Embodiment 3

[0025] Example 3 Euonymus Euonymus Extract Preparation 3

[0026] The extraction method of Euonymus euphonium ethyl acetate and n-butanol extract comprises the steps of: taking Euonymus euphonium medicinal material, beating into fine powder, passing through a 50-mesh sieve, and for subsequent use; Ethanol, soaked 3 times, soaked for 14 hours each time; the soaking solution was filtered through a 200-mesh sieve, suction filtered, and concentrated under reduced pressure until it had no alcohol smell, to obtain a concentrated solution; the concentrated solution was extracted with ethyl acetate and n-butanol in sequence, The extraction method is as follows: ethyl acetate and n-butanol are respectively extracted 3 times, and each time is 3 times the solvent amount of the concentrated solution according to the mass percentage. The extracts were combined, and then subjected to suction filtration, and the filtrate recovered the solvent and dried under reduced pressure to obtain the et...

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PUM

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Abstract

The invention provides an extraction method and purpose of ethyl acetate and n-butyl alcohol extracts of euonymus fortunei. The extraction method includes: immersing the medical materials in ethyl alcohol for extraction, filtering, performing suction filtration, sequentially extracting with ethyl acetate and n-butyl alcohol after concentration, and finally obtaining the ethyl acetate and n-butyl alcohol extracts via suction filtration and drying. Experimental data show that the two extracts have certain protection function on vascular endothelial cell oxidative damage and can be applied to preparation of cardiovascular disease medicine caused by vascular endothelial cell oxidative damage, and a solid foundation is laid for development of medicinal value of the euonymus fortunei of characteristic traditional Chinese medicine in Guangxi region.

Description

technical field [0001] The invention belongs to the technical field of medicinal liquid extraction, and in particular relates to an extraction method and application of ethyl acetate and n-butanol extracts of Euonymus vinifera. Background technique [0002] Vascular endothelial cells are a layer of cell groups that continuously cover the intima of blood vessels throughout the body. This cell group is not only a barrier for blood and tissues, but also has the ability to synthesize a variety of vasoactive substances. The role of vascular endothelial cells includes: regulating the relaxation and contraction of blood vessels by releasing vasoactive substances such as nitric oxide (NO) prostacyclin (PGI2) endothelin (ET) thromboxane A2 (TXA2) and other factors; providing an antithrombotic and anti-blood cell adhesion surface; synthesize and secrete some growth regulatory factors and cytokines, regulate normal physiological functions; regulate blood vessel permeability, vascular e...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P9/14A61P9/00
CPCA61K36/37A61K2236/33A61K2236/333
Inventor 农毅清蒋林罗宇东吴玉强谭安蔷
Owner PHARMA FACTORY OF GUANGXI TRADITIONAL CHINESE MEDICAL UNIV