A method for realizing fully automatic continuous preparation of microspheres

Abstract

The invention relates to a method for achieving fully-automatic and continuous preparation of a micro-balloon. The method comprises steps of: (1) pouring into samples to allow the sample to be uninterruptedly poured, wherein the samples comprise dispersion phases and continuous phases: a, detecting whether the samples reach an upper limit position in real time, if yes, stopping pouring into the samples and then entering step b, and if not, continuing to pour into the samples and executing the step a; and b, detecting whether the samples reach a lower limit position, in real time, if yes, starting to pour into the samples and returning to the step a, and if not, continuing to execute the step b; and (2) injecting the samples into a micro-flow control chip, carrying out precise control on the samples injected into a micro-channel, thereby achieving generation, transportation and combination of liquid drops, and after the liquid drops are generated, carrying out in-situ solidification to form a micro-balloon. According to the invention, through a CPU controlling injector and a switching valve, automatic extraction and pouring of liquid are achieved; it is ensured that there is liquid in the injector, thereby achieving continuous and stable preparation of the micro-balloon; and the whole process is free of manual interference, and operation parameters in an operation process can be recorded.

Description

technical field [0001] The invention relates to a method for realizing automatic and continuous preparation of microspheres, belonging to the technical field of microfluidic liquid droplets. Background technique [0002] Compared with traditional materials, microspheres have unique advantages such as small particles, large specific surface area, and good fluidity. In addition, microspheres have low toxicity, high efficiency, slow release, and long-acting characteristics in drug release, which is very important for improving drug utilization. The rate is of great significance, and has become an ideal carrier of growth factors, antibiotics, and anticancer drugs, and has attracted much attention. [0003] Microfluidic droplet technology generally refers to passing two immiscible fluids into the microfluidic chip as a dispersed phase and a continuous phase, and precisely controlling the fluid entering the microchannel, so as to realize the generation, transportation, Merging an...

AI Technical Summary

Problems solved by technology

The disadvantage of the existing preparation of microspheres is that the output of microspheres is greatly affected by the volume of the syringe. When the sample in the syringe is exhausted, the preparation of microspheres stops, and the preparation of microspheres must be manually added to the syringe, which cannot work continuously and stably for a long time. , can not achieve continuous automatic mass production, the whole process of human intervention is required in the preparation process

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