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Relationship of beta-catenin expression and neuroglioma patient prognosis

A technique for glioma, patients, applied in the field of biomedicine

Inactive Publication Date: 2016-12-28
宁波美丽人生医药生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant clinical data to confirm the relationship between AQP1 and β-catenin in human tumor tissues

Method used

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  • Relationship of beta-catenin expression and neuroglioma patient prognosis
  • Relationship of beta-catenin expression and neuroglioma patient prognosis
  • Relationship of beta-catenin expression and neuroglioma patient prognosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Expression of β-catenin in Glioma Patients

[0049] Previous studies have shown that AQP1 and β-catenin in glioma cells are closely related. On this basis, we hypothesized that this association would also apply to in vivo studies. Previous studies have shown that β-catenin is overexpressed in glioma, and its high expression is related to the malignancy of glioma (Liu et al.2011, Rossi et al.2011). In our study, β-catenin protein was mainly expressed in different intensities and locations in the cytoplasm ( Figure 4 D). Compared with low-grade (grade 1 and 2) gliomas, high-grade (grade 3 and 4) gliomas have a large amount of intracytoplasmic β-catenin protein expression. However, no significant nuclear staining was observed in specimens, including high-grade gliomas. High expression of β-catenin protein in grade 1 glioma and 39% of grade 2 glioma (n=24), but β-catenin in 55% of grade 3 glioma (n=30) and 58% of GBM (n=38) High expression of -catenin protein. For the...

Embodiment 2

[0051] Relationship between β-catenin protein expression and prognosis in patients with glioma

[0052] Kaplan-Meier analysis showed that high expression of β-catenin protein was associated with OS (P=0.034, Figure 5 E) and PFS (P=0.005, Figure 5 F) Significantly correlated. The median overall survival rate of patients with high expression of β-catenin protein was 31 months (95% Cl: confidence interval, 0.00-89.77), while the overall survival rate of patients with low expression of β-catenin protein (comprehensive score: 0-2) was 27 months (95% CI: confidence interval, 19.33-34.67). The median PFS of patients with high expression and low expression were 18 (95% Cl: confidence interval, 12.18-23.82) and 22 months (95% Cl: confidence interval, 7.65-36.36), respectively.

Embodiment 3

[0054] Relationship between AQP1 and β-catenin protein in glioma patients

[0055] Next, we investigated the relationship between AQP1 and β-catenin protein in glioma patients. Increased amounts of AQP1 and β-catenin proteins corresponded to histological grades. In addition, AQP1 labeling index was positively correlated with β-catenin protein expression (rs=0.168, P=0.022). High expression of AQP1 was significantly correlated with high-grade glioma and high expression of β-catenin protein.

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Abstract

The invention relates to the field of biological medicines and especially relates to a relationship of beta-catenin expression and neuroglioma patient prognosis cases. The inventor explores expression of beta-catenin in a cell model and a clinical sample. A research shows that beta-catenin is over expressed in neuroglioma and high expression of the beta-catenin is related to a malignancy grade (Liu et al. 2011, Rossi et al. 2011). Compared with low-level glioma (with levels 1 and 2), high-level glioma (with levels 3 and 4) has high expression of an intracytoplasmic beta-catenin protein. Beta-catenin expression and neuroglioma patient prognosis cases are in a certain relationship.

Description

Technical field: [0001] The invention relates to the field of biomedicine, in particular to the relationship between the expression of β-catenin and the prognosis of glioma patients. . Background technique: [0002] Aquaporins (AQPs) belong to a family of small hydrophobic intrinsic membrane proteins that mediate the transmembrane transport of water molecules involving osmotic pressure gradients (Verkman 2005). There are 13 kinds of aquaporins (AQP-AQP12) in mammals. Such AQPs can be divided into two functional groups: traditional aquaporins (AQP 1, 2, 4, 5, 8), which only facilitate the transport of water molecules; glycerol aquaporins (AQP 3, 7, 9, 10), which also Transport of small uncharged molecules such as glycerol, lactic acid and urea (verkman 2005). [0003] Because of the close relationship between AQPs and tumor development, its research has attracted public attention. The expression of AQP3 was up-regulated in liver, colon, cervical cancer, and in esophageal ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/57484G01N2800/52
Inventor 田晓丽
Owner 宁波美丽人生医药生物科技发展有限公司
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