RGD-SSL lipidosome for packaging turtle shell peptide and preparation method of lipidosome
A liposome and turtle shell peptide technology, which is applied in the field of RGD-SSL liposomes encapsulating turtle shell peptide and its preparation, can solve the problems of frequent administration and poor stability, reduce the frequency of administration, improve Effects of Local Biological Effects and Circulatory Half-Life
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[0024] The technical scheme of the present invention will be further described below through specific implementation examples:
[0025] 1. First prepare RGD-PEG2000-DSPE
[0026] The raw materials are: a cyclic peptide with arginine-glycine-aspartic acid (RGD) sequence, its structural formula is as formula II and a DSPE-Poly(Ethylene Glycol)-Maleimide, Average Mw 2000, namely DSPE-PEG2000 -Mal, its structural formula is as shown in formula III:
[0027]
[0028] The preparation method of RGD-PEG2000-DSPE comprises the following steps:
[0029] Precisely weigh an appropriate amount of RGD and DSPE-PEG2000-Mal powder and place them in PBS (pH 6.0, containing 3mM EDTA, pH 4.0) buffer solution to prepare the corresponding stock solution. The molar ratio of the same volume is 1:1. The two solutions were respectively made RGD:DSPE-PEG2000-Mal=x:1 (molar ratio, x=1, 1.5, 2), and incubated at 37°C for 2h after sufficient shaking. with 50mM Na 2 HPO 4 (pH=7.0) Prepare and prepa...
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