Preparation method of 3D printed PLGA intervertebral fusion cage coated with calcium phosphate cement

A technology of calcium phosphate bone cement and intervertebral cage, which is applied in 3D printing, coating, additive manufacturing and other directions, can solve the problems of too fast degradation of 3D printing cage, unmaintainable mechanical strength, enlargement of printing gap, etc. Biocompatibility, reduced contact, improved mechanical properties

Active Publication Date: 2019-09-20
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 3D printed fusion cages still face problems such as rapid degradation in vivo, mechanical strength cannot be maintained until bone fusion, and printing gaps will also enlarge such defects

Method used

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  • Preparation method of 3D printed PLGA intervertebral fusion cage coated with calcium phosphate cement
  • Preparation method of 3D printed PLGA intervertebral fusion cage coated with calcium phosphate cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]A 3D printed PLGA intervertebral fusion device coated with calcium phosphate bone cement. The degradable polyester PLGA intervertebral fusion device was prepared by 3D printing technology, and then the polymer surface was coated with calcium phosphate bone cement and the printing gap was filled. Phosphoric acid After the calcium bone cement is cured to form a hydroxyapatite coating, it is prepared as follows:

[0036] 1. Preparation of 3D printed PLGA intervertebral fusion cage:

[0037] Use PLGA (Mw=20W) as the printing "ink", the 3D printer is Bio-Architect ®-WS, the material is placed in the barrel of the high-temperature nozzle, the printing needle is 170μm, and the printing parameters are set: each layer is printed in parallel, and the gap is 0.2 mm, the Z-axis direction is increased layer by layer by 0.15mm, the layers are vertically cross-stacked, the printing temperature is 190°C, the extrusion speed is set to 2mm / s, and the temperature of the receiving platform ...

Embodiment 2

[0042] A 3D printed PLGA intervertebral fusion device coated with calcium phosphate bone cement, prepared according to the following steps:

[0043] 1. Preparation of 3D printed PLGA intervertebral fusion cage:

[0044] Use PLGA (Mw=20W) as the printing "ink", the 3D printer is Bio-Architect ®-WS, the material is placed in the barrel of the high-temperature nozzle, the printing needle is 170μm, and the printing parameters are set: each layer is printed in parallel, and the gap is 0.25 mm, the Z-axis direction is increased layer by layer by 0.15mm, the layers are vertically cross-stacked, the printing temperature is 190°C, the extrusion speed is set to 2mm / s, and the temperature of the receiving platform is 30°C. The cervical intervertebral fusion cage was printed, and this fusion cage was used as the control group.

[0045] 2. The preparation of gelatin-modified α-TCP is the same as in Example 1.

[0046] 3. Prepare Na with a mass fraction of 2.5% by magnetic stirring at roo...

Embodiment 3

[0048] A 3D printed PLGA intervertebral fusion device coated with calcium phosphate bone cement, prepared according to the following steps:

[0049] 1. Preparation of 3D printed PLGA intervertebral fusion cage:

[0050] Use PLGA (Mw=20W) as the printing "ink", the 3D printer is Bio-Architect ®-WS, the material is placed in the barrel of the high-temperature nozzle, the printing needle is 170μm, and the printing parameters are set: each layer is printed in parallel, and the gap is 0.3 mm, the Z-axis direction is increased layer by layer by 0.15mm, the layers are vertically cross-stacked, the printing temperature is 190°C, the extrusion speed is set to 2mm / s, and the temperature of the receiving platform is 30°C. The cervical intervertebral fusion cage was printed, and this fusion cage was used as the control group.

[0051] 2. The preparation of gelatin-modified α-TCP is the same as in Example 1.

[0052] 3. Prepare Na with a mass fraction of 2.5% by magnetic stirring at room...

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Abstract

The invention relates to a preparation method of a 3D printed PLGA intervertebral fusion cage coated with calcium phosphate cement. The polyester PLGA intervertebral fusion cage can be degraded through the 3D printing technology, the surface of a polymer is coated with the calcium phosphate cement, the printing clearance is filled, and the calcium phosphate cement is solidified to form a hydroxyapatite coating. The preparation method is expected to solve problems faced by the application of degradable materials in the field of intervertebral fusion cage, such as excessive degradation in vivo, large acidity of degradation products and insufficient mechanical properties, meanwhile, the 3D printing technology provides a novel path for clinical individualized preparation of the intervertebral fusion cage in accordance with human anatomy, and a broad clinical application prospect is achieved.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a method for preparing a 3D printed PLGA intervertebral fusion device coated with calcium phosphate bone cement. Background technique [0002] With the continuous development and improvement of spinal intervertebral fusion technology, intervertebral fusion has become the mainstream surgical mode and gold standard for the treatment of spinal degeneration, deformity, fracture, tumor, tuberculosis and other spinal related diseases. However, with the increasing number of spinal intervertebral fusion operations, reports of long-term postoperative complications such as intervertebral fusion cage subsidence have gradually increased in recent years [Wang Peng, Sun Guisen, Li Hongqi, etc., China Tissue Engineering Research, 2018] , there are many factors causing this phenomenon, such as osteoporosis and old age [Brunello G, Sivolella S, Meneghello R, Biotechnology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44A61L27/18A61L27/32A61L27/50A61L27/58
CPCA61F2/4455A61F2002/30003A61F2002/30064A61F2002/30985A61L27/18A61L27/32A61L27/50A61L27/58A61L2430/38C08L67/04
Inventor 杨迪诚
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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