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An anti-obesity drug containing wild chrysanthemum extract

A wild chrysanthemum and obesity technology, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of anti-obesity drug safety and poor efficacy, achieve good fat cell differentiation, and reduce oil droplets and triglycerides, the effect of inhibiting the differentiation of adipocytes

Inactive Publication Date: 2019-12-20
广州市爱菩新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of poor safety and curative effect of the existing anti-obesity drugs, the present invention provides an active ingredient of wild chrysanthemum extract, which can significantly inhibit the differentiation of 3T3-L1 preadipocytes and reduce the oil droplets in 3T3-L1 preadipocytes. , anti-obesity drugs that accumulate triglycerides

Method used

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  • An anti-obesity drug containing wild chrysanthemum extract
  • An anti-obesity drug containing wild chrysanthemum extract
  • An anti-obesity drug containing wild chrysanthemum extract

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment provides an anti-obesity drug containing the extract of Chrysanthemum officinalis, which consists of the extract of Chrysanthemum officinalis and / or a pharmaceutically acceptable carrier. Wild chrysanthemum extract contains sesquiterpenoids with the following structure:

[0029]

[0030] The above-mentioned wild chrysanthemum extract is prepared by the following method. In this example, the physiological activity analysis of the sesquiterpenoids in the wild chrysanthemum extract was also carried out.

[0031] The preparation method of wild chrysanthemum extract comprises the following steps:

[0032] (1) extraction

[0033] Weigh 7.0Kg of dried wild chrysanthemum, soak the dried wild chrysanthemum with 10L of ethanol (95%) at normal temperature and pressure for 24h, then filter, and collect the filtrate. Repeat the extraction of Flos Chrysanthemum for three times, combine the filtrates extracted three times, and then place the filtrate in a water b...

Embodiment 2

[0124] This example provides an anti-obesity drug containing the extract of Chrysanthemum chrysanthemum, which contains Compound 1 described in Example 1 and / or a pharmaceutically acceptable carrier, and the active ingredient is Compound 1.

[0125] From the test results in Example 1, it can be seen that the anti-obesity drug containing the chrysanthemum extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides during the differentiation process of 3T3-L1 preadipocytes, that is, the anti-obesity drug of this example Obesity drugs have a good effect of inhibiting the differentiation of adipocytes and reducing oil droplets and triglycerides in adipocytes, and have good development prospects in the treatment of obesity.

Embodiment 3

[0127] This example provides an anti-obesity medicine containing the extract of Chrysanthemum chrysanthemum, which contains Compound 2 described in Example 1 and / or a pharmaceutically acceptable carrier, and the active ingredient is Compound 2.

[0128] From the test results in Example 1, it can be seen that the anti-obesity drug containing the chrysanthemum extract of this example has the effect of reducing the accumulation of oil droplets and triglycerides during the differentiation process of 3T3-L1 preadipocytes, that is, the anti-obesity drug of this example Obesity drugs have a good effect of inhibiting the differentiation of adipocytes and reducing oil droplets and triglycerides in adipocytes, and have good development prospects in the treatment of obesity.

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Abstract

The invention specifically relates to an anti-obesity drug containing wild chrysanthemum flower extract, belonging to the technical field of anti-obesity drugs. The wild chrysanthemum flower extract in the anti-obesity drug contains sesquiterpenoids disclosed in the invention; the sesquiterpenoids can substantially inhibit accumulation of triglyceride and total fat in the differentiation process of 3T3-L1 preadipocytes, and the inhibitory effect is superior to the inhibitory effect of a positive control compound, i.e., berberine. Thus, the n anti-obesity drug containing the wild chrysanthemum flower extract in the invention has good effect on inhibition of adipocyte differentiation and reduction in oil droplets and triglycerides in the adipocytes, and has good development prospect in treatment of obesity.

Description

technical field [0001] The invention relates to the technical field of anti-obesity drugs, in particular to an anti-obesity drug containing wild chrysanthemum extract. Background technique [0002] In recent years, with the changes in people's lifestyle and diet structure, the number of obese people in the world has increased sharply, and it has become a worldwide public health problem that threatens human health and quality of life. Obesity may lead to a series of metabolic diseases, such as diabetes, hypertension, hyperlipidemia, fatty liver and certain cancers, so it is already the fifth leading cause of death in the world. At present, there are only a handful of drugs that can be used clinically to treat obesity, and the safety and efficacy are still inconclusive. [0003] The pathogenesis of obesity is complex, and currently there is no good drug target. During the development of weight loss drugs, many drugs work by acting on the neural feeding center, because various...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61K36/287A61P3/04
Inventor 徐峻李婵娟顾琼
Owner 广州市爱菩新医药科技有限公司
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