Preparation method of high-concentration D-arabinose

A high-concentration technology of arabinose, applied in the field of functional sugars, can solve the problems of low yield of D-arabinose, high production cost, complicated process, etc., and achieve the effect of simple extraction and crystallization steps, reduced production costs, and rich applications

Active Publication Date: 2017-01-25
山东福洋生物科技股份有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention provides a method for preparing high-concentration D-arabinose to solve the problems of complex existing processes, expensive intermediate raw materials, low yield of D-arabinose, and high production costs. It is difficult to obtain a high-concentration D-arabinose oxidation catalytic method, which leads to difficulties in post-extraction methods such as subsequent concentration and crystallization, and it is difficult to obtain high-purity D-arabinose crystals; or leads to complicated post-extraction steps

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  • Preparation method of high-concentration D-arabinose

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[0024] In one embodiment of the present invention, the preparation method of the high-concentration D-arabinose of the present invention comprises the following steps:

[0025] 1), adding a catalyst to the sodium gluconate solution, adding hydrogen peroxide and sodium gluconate, and oxidizing to prepare D-arabinose solution;

[0026] 2), refined to obtain D-arabinose liquid;

[0027] 3) Crystallization to prepare D-arabinose crystals.

[0028] In one embodiment of the present invention, in the method for preparing high-concentration D-arabinose of the present invention, the catalyst in the above step 1) is a soluble iron salt. More preferably, in yet another embodiment of the present invention, in the method for preparing high-concentration D-arabinose in the present invention, the catalyst in step 1) is ferric chloride, ferrous sulfate, and ferric sulfate. More preferably, in yet another embodiment of the present invention, in the preparation method of the high-concentratio...

Embodiment 1

[0035] (1) Oxidation to prepare high-concentration D-arabinose crude solution

[0036] The raw material formula of D-arabinose liquid adopts mass percent, and 175 grams of sodium gluconate are added in the 3 liters of reaction tanks that are added with 1176 grams of water, make concentration be 13% weight 1354g, add 2.98g of soluble iron salt iron sulfates as catalyst, The consumption of catalyst is 0.017 of the molar weight of sodium gluconate.

[0037] Such as figure 1 Shown, the sodium gluconate that feeds is added according to tail gas (oxygen) mass spectrometer system control feeds in the reaction process, and oxygen amount is controlled at 0.06-0.09moL / (L h), and the sodium gluconate mass concentration that feeds is 60% And the feeding liquid is placed in an environment of 80° C. to prevent the crystallization of sodium gluconate, and the feeding amount is 38-42 g / (L·h). The flow acceleration rate changes according to the change of tail oxygen. When the tail oxygen is ...

Embodiment 2

[0052] (1) Preparation of D-arabinose solution

[0053] The D-arabinose liquid raw material formula adopts mass percentage, and 175 gram sodium gluconate is added in the 3 liters of reaction tanks that are added with 1060 gram water, is made into mass percentage concentration and is 14% weight 1235g, and sodium gluconate is according to process oxygen tail mass spectrometer The system counter-controls feed feeding, the oxygen amount is controlled at 0.08-0.09moL / (L h), the mass concentration of sodium gluconate fed into feed is 60%, and the fed feed liquid is placed in an environment of 80°C to prevent sodium gluconate from crystallizing. The amount is 38-42g / (L·h). Slowly add hydrogen peroxide while stirring, hydrogen peroxide concentration is 30% weight 800mL in hydrogen peroxide, temperature of reaction is 50 ℃, the adding speed of hydrogen peroxide is 150-300mL / h, the equivalent of hydrogen peroxide is 5 times of sodium gluconate equivalent.

[0054] (2) Refining of D-ara...

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Abstract

The invention provides a preparation method of high-concentration D-arabinose. The method comprises the following steps: adding a catalyst into sodium gluconate, feeding hydrogen peroxide and sodium gluconate in a flowing manner, oxidizing, preparing D-arabinose liquid, and the like, wherein the feeding rate of the sodium gluconate is determined according to an oxygen content in reaction tail gas. By adopting the method, high-concentration conversion from the sodium gluconate to D-arabinose is realized, and the concentration of the obtained D-arabinose can reach 35 to 80 percent of the total mass of a dry matter, so that the subsequent extraction and crystallizing step is simple; and the production cost of the D-arabinose is reduced.

Description

technical field [0001] The invention belongs to the technical field of functional sugars, in particular to a method for preparing high-concentration D-arabinose. Background technique [0002] D-arabinose is widely used in the field of biomedicine and functional food. D-arabinose or its oxidized D-arabinonic acid can be used to produce riboflavin and vitamin B, which are components of prosthetic groups of flavin enzymes in the body 2 . D-arabinose is also an intermediate in the production of the anticancer drug cytarabine. These uses are limited by the high price due to the absence of a process for the economical production of D-arabinose at low cost. There are several methods for producing D-arabinose. [0003] British patent 953012, which is a patent applied by Sankyo Company, is a method for preparing D-arabinose by a fully synthetic process. This method needs to prepare five intermediate reaction products, so considering industrialization, the process is too complica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H3/02C07H1/06C07H1/00
Inventor 赵伟张曰辉朱萌萌徐姣姣
Owner 山东福洋生物科技股份有限公司
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