Application of penemenol e1 derived from Trichoderma aurantii in the preparation of anti-lymphoma drugs

A technology of penemol and Trichoderma citri, applied in the field of medicinal chemistry, can solve problems such as no drugs, and achieve the effect of significant anti-lymphoma activity
CN106420715BActive Publication Date: 2019-07-09FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2019-07-09

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Abstract

The invention relates to application of penicillium enol E1 deriving from trichoderma citrinoviride in preparation of an anti-lymphoma drug. The compound is structurally characterized by containing a molecular skeleton of pentacyclic amide and a carbonyl group connected with a deca-carbon saturated fat long chain, wherein a methyl group is connected with N, and a molecule comprises two hydroxyl groups. It is verified through experiments that the alkaloid compound has good inhibitory activity on lymphoma and can be used for preparing a drug for inhibiting lymphoma cell proliferation or the anti-lymphoma drug and used in anti-tumor research.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and relates to the application of penemenol E1 derived from Trichoderma aurantii in the preparation of anti-lymphoma drugs. Background technique

[0002] Alkaloids are a type of nitrogen-containing organic compounds produced by biological secondary metabolism. There are many types of alkaloids in nature, most of which come from plants, so they are also called plant alkaloids. Alkaloids have important physiological effects on humans and animals, including anti-asthma and antitussive, hypoglycemic, hypolipidemic, antibacterial, antitumor, analgesic, etc., among which antibacterial and antitumor activities are the most prominent. Natural structural alkaloids are an important source for discovering lead compounds in the research of innovative drugs, and there are nearly a hundred kinds of alkaloid drugs currently used in clinical practice. Studies have found that some marine fungi can produce alka...

Claims

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