Therapeutic proteins and methods of using the same for treating cancer
A technology of protein and chimeric protein, applied in the field of therapeutic protein, can solve the problems of patients getting sick and deficient disease
Active Publication Date: 2021-08-27
PRODA BIOTECH +1
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However, these treatments often cause the patient to feel sick during treatment and are often not sufficient to completely remove the disease from humans
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[0051] The present disclosure is not limited to the particular embodiments described in the
[0052] As will be apparent to those skilled in the art, each of the individual embodiments described and illustrated herein will be readily separated from any of several other embodiments in any of several other embodiments. The composition and characteristics, without departing from the scope or spirit of the disclosure. Any of the methods can be implemented in the order of the events or in any other order in logically.
[0053] Unless otherwise stated, the embodiments of the present disclosure will utilize pharmaceutical, organochemical, biochemical, molecular biology, pharmacology, and the like, which are in the art. These techniques are fully explained in the liter...
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Therapeutic proteins for inducing apoptosis in cells and methods of using such proteins are described. Proteins, such as chimeric proteins, have a host peptide fused to a more stable BH3 domain peptide. The host peptide may be calcium binding protein D9k, the N-terminal or C-terminal half-domain of calmodulin, parvalbumin ("Pa"), amino acid sequence variants thereof, or modified variants thereof. The BH3 domain can be Bim, Bid, Bad, Bik, Bmf, Hrk, Puma or Noxia. Also, various conjugates can be attached to chimeric proteins, including folic acid and polyethylene glycol.
Description
[0001] Related application data [0002] The present application claims priority to US Temporary Patent Application Serial No. 61 / 949, 345, filed on March 7, 2014, incorporated herein by reference. Technical field [0003] The present disclosure generally relates to the treatment of proteins, and more particularly to proteins having increased stability, such as chimeric proteins, and treat agents in the treatment of cancer and other diseases. Background technique [0004] Cancer and other diseases affect the daily life of humans. Cancer is particularly due to persistent diseases that spread throughout the body body caused by the death of the cell procedure until the host finally died of the disease. [0005] Currently use various forms of treatment methods, the scope is treated from invasive to extreme micro-invasive treatment for these diseases. These treatments include surgical, chemotherapy, radiation therapy, targeted treatment, and the like. However, these treatments often le...
Claims
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IPC IPC(8): A61K38/00C07K17/00G01N33/574
CPCA61K38/00C07K14/47C07K2319/00A61K47/60A61K47/551A61K47/545A61K31/282A61K38/1738A61K38/1761A61K49/0002C07K14/4728C07K14/4747
Inventor 刘志仁
Owner PRODA BIOTECH