saRNA molecules of TPO genes and application of saRNA molecules

A molecular and genetic technology, applied in the field of molecular biology, can solve the problems of short residence time and limited clinical application value.
CN106480028AActive Publication Date: 2017-03-08SHANGHAI SEVENTH PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI SEVENTH PEOPLES HOSPITAL
Publication Date
2017-03-08

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Abstract

The invention relates to the field of molecular biology medicine. saRNA molecules of TPO genes are synthesized, the sequence of the saRNA molecules and the sequence SEQ ID NO:1 of the upstream 6,000bp and downstream 1,000bp areas of a TPO gene transcriptional start site are complementary, and low-expression or non-expression TPO genes in tumor cells can be effectively activated. A biological effect of promoting the tumor cells to hold radionuclide 131I is achieved, a novel method and novel molecular targets are provided for combining the gene technology with the radionuclide therapy for targeted therapy of tumors.
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Description

technical field

[0001] The invention relates to the technical field of molecular biology, in particular to the saRNA molecule of TPO gene and its application. Background technique

[0002] Gene therapy is a new treatment method that introduces normal genes or therapeutic genes into target cells to achieve the purpose of disease treatment. In recent years, many studies on gene therapy methods for tumors have been carried out all over the world. Among them, RNA activation (RNA activation, RNAa) is a new gene technology discovered and developed in recent years. The expression technology can activate the endogenous gene of the cell, so as to realize the new technology of up-regulating the expression of the target gene. The development of RNA activation technology provides an extremely promising option for combining gene technology with radionuclide therapy for targeted treatment of tumors.

[0003] Sodium iodide symporter (Human sodium iodide symporter, hNIS) and human thyroid...

Claims

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