Application of Astragalus Powder in the Preparation of Drugs for Preventing or Treating Alzheimer's Disease

A technology of Alzheimer's disease and Radix Astragali, which is applied in the application field of Huangqi powder and medicine, can solve the problems of poor efficacy of Alzheimer's disease, achieve prevention and treatment of Alzheimer's disease, improve cognitive decline, inhibit The effect of Alzheimer's disease

Active Publication Date: 2019-12-24
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a new use of Huangqi Powder, which will solve the poor effect of traditional Chinese medicines in the prior art on preventing and treating Alzheimer's disease. technical issues

Method used

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  • Application of Astragalus Powder in the Preparation of Drugs for Preventing or Treating Alzheimer's Disease
  • Application of Astragalus Powder in the Preparation of Drugs for Preventing or Treating Alzheimer's Disease
  • Application of Astragalus Powder in the Preparation of Drugs for Preventing or Treating Alzheimer's Disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1.1 Transgenic mouse model:

[0044] The Alzheimer's disease double transgenic mouse model APPswe / PS1dE9 (APPswe, Swiss familial AD-induced mutant type, presenilin1, presenilin 1)) model used in the present invention was purchased from Nanjing Institute of Model Animals. They were kept in the animal room of Shanghai University of Traditional Chinese Medicine. The strain name of Jackson Laboratory: B6C3-Tg (APPswe, PSEN1dE9) 85Dbo / J; serial number 004462. This double-transgenic Alzheimer's disease model mouse expresses the Swiss familial AD-induced mutant of human APP and the mutant of PS1 with the deletion of the ninth intron mutation site. These two genes Mutations genetically co-segregate in this mouse. This mouse model usually begins to deposit amyloid plaques in the brain at 6 months of age, and develops learning and memory impairments at 9 months of age, with pathological manifestations similar to Alzheimer's disease. Raised in SPF rat room, provided with suffic...

Embodiment 2

[0090] 2.1 Chinese medicine extraction and feed preparation

[0091] The present invention is composed of Radix Astragali, Radix Puerariae and Cortex Mori, the mass ratio of Radix Astragali, Radix Puerariae and Cortex Morus is 1:2:1. Astragalus membranaceus and Cortex Morus alba were crushed together and extracted twice with ethanol with a concentration of 70% by mass percentage, extracted for 2 hours each time, filtered through 100 mesh, combined with two extracts, concentrated under reduced pressure to 2g / ml, vacuumed at 75°C Dried to dry extract, 786.5g was obtained, and the yield was 19.66%. (The following experiments all use this component to feed)

[0092] This experiment has prepared the mouse feed of the present invention of two doses: 1) low-dose feed, the extractum that adds 20g Radix Astragali, 40g Radix Puerariae Radix, 20g Cortex Mori crude drug is made into low-dose mouse feed by every kilogram of feed. 2) The high-dose feed is made by 3 times the dose of the l...

Embodiment 3

[0109] Example 3 Immunohistochemistry and Quantification

[0110] 3.1 Fixation and sectioning of mouse brain tissue

[0111] After feeding APP / PS1 Alzheimer's disease transgenic mice with the feed of the present invention for 6 months, the mice were anesthetized by intraperitoneal injection of 12% chloral hydrate (400mg / Kg), and the chest cavity was quickly opened after the mice were deeply anesthetized , expose the heart, perfuse the heart with 50mL of 0.9% sodium chloride aqueous solution and continue to perfuse with 100mL of fixative solution (4% paraformaldehyde). hours, and then put the brain tissue into 30% sucrose solution. After the brain tissue was settled, frozen sections were performed on a slide microtome (Lecia Company). We mainly studied the hippocampus and cortex regions of the brain slices (from bregma-1.92 to -4.36mm). The thickness of the brain slices was 25 μm, and 1 of 6 were placed in the same hole, and 6 sets of brain tissue slices could be obtained for...

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Abstract

The invention provides application of astragalus powder in preparation of medicines for preventing or curing alzheimer disease. The astragalus powder is composed of astragali, kudzu vine roots and white mulberry root bark according to the mass proportion of 1:2:1. Pharmacodynamic tests prove that the astragalus powder has the functions of inhibiting occurrence and development of cerebral pathology of alzheimer disease and improving the situation of cognitive function decline due to alzheimer disease, and can effectively prevent and cure alzheimer disease.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to Huangqi powder, in particular to the application of Huangqi powder in the preparation of medicines for preventing or treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is the most common degenerative disease of the central nervous system and the most common type of senile dementia. The clinical pathology of AD mainly manifests as persistent cognitive decline and progressive memory ability. decline, motor dysfunction, personality changes, language dysfunction, and eventually dementia. The neuropathological features of Alzheimer's disease are mainly the deposition of senile plaques (Senile plaques, SPs) outside the cells, the accumulation of neurofibrillary tangles (Neurofibrillary tangles, NFTs) inside the cells and the death of neurons in specific brain regions. The disease was first reported on November 3, 1906, by German psychiatrist ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K9/14A61P25/28
CPCA61K9/141A61K36/481A61K36/488A61K36/605A61K2300/00
Inventor 柯尊记黄诚张颖贾新玲丁涵青袁琳骆嘉
Owner SHANGHAI UNIV OF T C M
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