Yttrium-doped calcium phosphate bone cement and preparation method thereof

A calcium phosphate bone cement, yttrium-doped technology, applied in medical science, prosthesis, etc., can solve problems such as low mechanical properties, achieve the effect of improving mechanical properties, retaining curing properties, and good biological activity

Active Publication Date: 2017-03-22
JIANGXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the low mechanical properties of calcium phosphate bone cement have always been an important factor limiting its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Calcinate dibasic calcium phosphate dihydrate to 450°C in a muffle furnace and keep it warm for 1h, the heating rate is 150°C / h, cool with the furnace, grind finely, and pass through a 200 mesh sieve; mix the above phosphate with analytically pure calcium carbonate at 1 : 1 molar ratio mixed, mixed with Y / Y+Ca molar ratio of 2% yttrium nitrate hexahydrate Y (NO 3 ) 3 ·6H 2 O, using absolute ethanol as the medium, ball milled in a planetary ball mill for 8 hours and then dried. Put the dried ball-milled mixture into a high-temperature crucible, and carry out solid-state reaction in a high-temperature furnace. The firing system is to raise the temperature from room temperature to 400°C in 2 hours, then raise the temperature to 1500°C in 5 hours, and keep it at 1500°C for 6 hours; The reactant was taken out and quenched in the air, and after cooling, it was ground for a while, put into a ball mill for dry grinding for 6 hours, and passed through a 200-mesh sieve to obtai...

Embodiment 2

[0025] Calcinate dibasic calcium phosphate dihydrate to 450°C in a muffle furnace and keep it warm for 1h, the heating rate is 150°C / h, cool with the furnace, grind finely, and pass through a 200 mesh sieve; mix the above phosphate with analytically pure calcium carbonate at 1 : 1 molar ratio mixed, mixed with Y / Y+Ca molar ratio of 1.5% yttrium nitrate hexahydrate Y (NO 3 ) 3 ·6H 2 O, using absolute ethanol as the medium, ball milled in a planetary ball mill for 6 h and then dried. Put the dried ball-milled mixture into a high-temperature crucible, and carry out solid-state reaction in a high-temperature furnace. The firing system is to raise the temperature from room temperature to 400°C in 2 hours, then raise the temperature to 1500°C in 5 hours, and keep it at 1500°C for 6 hours; The reactant was taken out and quenched in the air, and after cooling, it was ground for a while, put into a ball mill for dry grinding for 6 hours, and passed through a 300-mesh sieve to obtain ...

Embodiment 3

[0028] Calcinate dibasic calcium phosphate dihydrate to 450°C in a muffle furnace and keep it warm for 1h, the heating rate is 150°C / h, cool with the furnace, grind finely, and pass through a 200 mesh sieve; mix the above phosphate with analytically pure calcium carbonate at 1 : 1 molar ratio mixed, mixed with Y / Y+Ca molar ratio of 2.5% yttrium nitrate hexahydrate Y (NO 3 ) 3 ·6H 2 O, with absolute ethanol as the medium, ball milled in a planetary ball mill for 10 h and then dried. Put the dried ball-milled mixture into a high-temperature crucible, and carry out solid-state reaction in a high-temperature furnace. The firing system is to raise the temperature from room temperature to 400°C in 2 hours, then raise the temperature to 1550°C in 5 hours, and keep it at 1550°C for 8 hours; The reactants were taken out and quenched in the air. After cooling, they were ground for a while, put into a ball mill for dry grinding for 8 hours, and passed through a 300-mesh sieve to obtain...

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Abstract

The invention discloses yttrium-doped calcium phosphate bone cement and a preparation method thereof. The preparation method comprises the steps that yttrium-doped tetracalcium phosphate powder which has certain granularity distribution and is prepared by a certain molar ratio and calcium hydrophosphate powder are mixed evenly, a certain amount of distiller liquid is added, and the ratio of solid phases to liquid phases is 2-6 g/mL. A bone cement curing product is the yttrium-doped hydroxyapatite and residual yttrium-doped tetracalcium phosphate under the physiological environment. A yttrium compound is successfully applied to the calcium phosphate bone cement, the mechanical property of the calcium phosphate bone cement is remarkably improved on the basis of not reducing the porosity, the curing performance of the calcium phosphate bone cement is reserved, the curing product has better biological activity, and the calcium phosphate bone cement has broader clinical application prospects compared with traditional calcium phosphate bone cement.

Description

technical field [0001] The invention belongs to the field of medical materials for bone defect repair, in particular to a yttrium-doped calcium phosphate bone cement and a preparation method thereof. Background technique [0002] Hydroxyapatite is widely used in hard tissue repair materials due to its similarity to apatite in biological bone and dental tissue in terms of morphology, crystal structure, synthesis and crystallinity. Rare earth elements have a variety of biological activities. By changing the permeability of the cell membrane, the surface of the cell membrane, and DNA synthesis, they have different effects on the growth of cells. They have anticoagulant and tissue growth promotion, antitumor, and antimutagenic Effect and anti-inflammatory, bactericidal effect. [0003] Due to the unique properties of rare earth elements, some researchers envisage adding a small amount of rare earth elements to biomedical materials; among them, doping a small amount of rare eart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50
Inventor 漆小鹏邹晓萍
Owner JIANGXI UNIV OF SCI & TECH
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