Antibody guided vaccines and methods of use for generation of rapid mature immune responses

An antibody and vaccine technology, applied in the direction of anti-animal/human immunoglobulin, antibody medical components, chemical instruments and methods, etc., can solve the problems of antigen consumption and time-consuming
CN106535932AInactive Publication Date: 2017-03-22阿肯色大学评议会 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
阿肯色大学评议会
Publication Date
2017-03-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and slgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided.
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Description

[0001] Cross References to Related Applications

[0002] This patent application claims priority to US Provisional Patent Application No. 62 / 008,178, filed June 5, 2014, which is hereby incorporated by reference in its entirety.

[0003] Statement Regarding Federally Funded Research

[0004] This invention was made with US Government support under Grant Number 2008-35204-04554 awarded by the National Institute of Food and Agriculture. The United States has certain rights in this invention.

[0005] sequence listing

[0006] This application includes a Sequence Listing submitted electronically in .txt format. The .txt file contains a sequence listing named "2015-05-29_5658-00264_ST25.txt", created on May 31, 2015, with a size of 43,879 bytes. The sequence listing contained in this .txt file is part of the specification and is hereby incorporated by reference in its entirety. Background technique

[0007] Mucosal surfaces are extensive surface areas that are the primary ent...

Claims

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