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Modified cyclodextrin preparation method

A cyclodextrin modification technology, which is applied in the field of preparation of modified cyclodextrin, can solve the problem that the water solubility of modified cyclodextrin has not been significantly improved, and achieve the effect of less steps, high water solubility and simple process

Inactive Publication Date: 2017-04-19
CHANGSHU KAILIDA HONEYCOMB PACKING MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103642190A mentioned modified cyclodextrin with polyethylene glycol, and its water solubility of the modified cyclodextrin prepared according to its preparation method has not been significantly improved. Therefore, it is very difficult to find a method that can obviously improve the solubility of cyclodextrin. have practical significance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add 1135g of ethanol and 1mol of β-cyclodextrin (1135g) into the reaction flask, stir at 10°C for 0.5h, then add 1mol of polyethylene glycol monocyclohexyl ether with a molecular weight of 1500 at this temperature, and keep stirring at this temperature 24h. Finally, the ethanol is evaporated to obtain the modified cyclodextrin.

Embodiment 2

[0016] Add 3891g of ethanol and 1mol of γ-cyclodextrin (1297g) into the reaction bottle, stir at 60°C for 0.5h, then add 3mol of polyethylene glycol monocyclohexyl ether with a molecular weight of 1000 at this temperature, and keep stirring at this temperature 10h. Finally, the ethanol is evaporated to obtain the modified cyclodextrin.

Embodiment 3

[0018] Add 5675g of ethanol and 1mol of β-cyclodextrin (1135g) into the reaction bottle, stir at 80°C for 0.5h, then add 2mol of polyethylene glycol monocyclohexyl ether with a molecular weight of 300 at this temperature, and keep stirring at this temperature 1h. Finally, the ethanol is evaporated to obtain the modified cyclodextrin.

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Abstract

The invention provides a modified cyclodextrin preparation method, and belongs to the technical field of the preparation of oligosaccharides. The method comprises the steps of adding ethanol and cyclodextrin into a reaction flask, stirring at a certain temperature for 0.5 hour, adding polyethylene glycol monocyclic ether in the reaction flask at the above temperature, stirring for 1-24 hours while maintaining the temperature to be unchanged, and finally evaporating the alcohol to obtain the modified cyclodextrin. The method has fewer steps and is simple in process. Meanwhile, equipment applied to the method is simple, so that the cost is lowered. The polyethylene glycol monocyclic ether comprises both hydrophilic groups and lipophilic groups and is good in intermolecular affinity for cyclodextrin. Therefore, the prepared polyethylene glycol monocyclic ether-modified cyclodextrin is better in water solubility compared with native cyclodextrin.

Description

technical field [0001] The invention belongs to the technical field of oligosaccharide preparation, and in particular relates to a preparation method of modified cyclodextrin. Background technique [0002] Cyclodextrin (CD for short) is a general term for a series of cyclic oligosaccharides produced by the fermentation of amylose under the action of cyclodextrin glucosyltransferase produced by Bacillus, usually containing 6-12 D-pyridine glucopyranose unit. Among them, molecules with 6, 7, and 8 glucose units that have been studied more and have important practical significance are called α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin, respectively. It can form host-guest inclusion complexes with many inorganic and organic molecules, and can change the chemical and physical properties of the inclusion complexes. It has the characteristics of protecting, stabilizing, solubilizing guest molecules and selectively orienting molecules. Therefore, it is used in food, environme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/16C08G81/00
CPCC08B37/0012C08G81/00
Inventor 方云祥
Owner CHANGSHU KAILIDA HONEYCOMB PACKING MATERIALS
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