Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of solid pharmaceutical composition containing sarcogrelate hydrochloride

A technology of sarcogrelate hydrochloride and its composition, which is applied in the field of sarcogrelate hydrochloride oral solid composition, and can solve the problems of poor selectivity and the like

Active Publication Date: 2020-08-21
TIANJIN CHASE SUN PHARM CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent of this drug expired at the end of April 2006, but so far no generic drug of this product has passed the declaration in domestic enterprises
The drugs used in the past are purely inhibiting platelet aggregation, and the selectivity is not strong or simply dilating blood vessels

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of solid pharmaceutical composition containing sarcogrelate hydrochloride
  • A kind of solid pharmaceutical composition containing sarcogrelate hydrochloride
  • A kind of solid pharmaceutical composition containing sarcogrelate hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 50

[0104] Example Preparation of film-coated tablets of 50mg and 100mg sargresil hydrochloride

[0105] prescription:

[0106]

[0107] The above formulation is prepared into film-coated tablets through the following steps:

[0108] a. Weigh the prescribed amount of sagogrelate hydrochloride and citric acid and crush them through a 100 mesh sieve, lactose and starch through a 100 mesh sieve, hydroxypropyl cellulose and hypromellose through 80 mesh, and magnesium stearate through 60 mesh. Sieve, spare;

[0109] b. Weigh the prescribed amount of hypromellose and prepare a 2.5% solution with purified water as a binder for use;

[0110] c. Take the prescription amount of citric acid, hydroxypropyl cellulose and an appropriate amount of lactose monohydrate, double and mix, and mix with the prescription amount of sargrelate hydrochloride, starch, and the remaining lactose monohydrate, and set aside;

[0111] e. Add adhesive to make soft material. Granulate with 24 mesh sieve, dry at 60±5℃, loss...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
hardnessaaaaaaaaaa
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a solid drug composition containing sarpogrelate hydrochloride, a preparation process and an application. Through selecting components and dosage of every auxiliary material in the preparation, a sarpogrelate hydrochloride coating tablet is obtained; the tablet is proper in disintegration; the hardness, and friability, and other indexes can reach the requirement of the coating process; the solid drug composition is featured by simple production process, convenience in production and stable quality.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an oral solid composition of sargresil hydrochloride and its preparation process and application. Background technique [0002] Sarpogrelate hydrochloride is a serotonin (5-HT2) receptor blocker that can specifically bind to 5-HT2 receptors. Serotonin (5-HT) was first proposed in 1955 as a vasoactive substance. 5-HT is widely present in animals, especially in the cardiovascular system. Except for a small part of it is re-ingested and stored in platelets, almost all 5-HT is inactivated by the endothelial cells of the liver and lungs. Sagrelate hydrochloride can specifically bind to 5-HT2 receptors and exhibit a special antagonistic effect on platelets and receptors on vascular smooth muscle. Therefore, it exhibits antiplatelet effect and inhibits vasoconstriction, and exerts a series of biological effects. Sargresil hydrochloride is an antithrombotic drug, mainly used to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K31/225A61K47/38A61P7/02A61P9/10
CPCA61K9/2059A61K9/2866A61K31/225
Inventor 魏征韩冬阚晓臣王桂霞郭新荣李宝齐郭嘉林孔凯董凯
Owner TIANJIN CHASE SUN PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products