Medicinal composition for promoting gastric motility, and preparation method and application thereof

Abstract

The invention provides a medicinal composition for promoting gastric motility. The medicinal composition comprises Rabdosia amethystoides extract, Fructus Aurantii extract and red ginseng extract, wherein a mass ratio of the Rabdosia amethystoides extract to the Fructus Aurantii extract to the red ginseng extract is (1-2):(5-10):(10-60). A preparation method of the medicinal composition is characterized in that the Rabdosia amethystoides extract, the Fructus Aurantii extract and the red ginseng extract are uniformly mixed according to the mass ratio of (1-2):(5-10):(10-60) to obtain the medicinal composition. The preparation method is simple, and is suitable for industrial production. The invention also provides an application of the medicinal composition in the preparation of medicines for promoting gastric motility. The medicinal composition can effectively promote the gastric motility, and has small side effects.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for promoting gastric motility, a preparation method and application thereof. Background technique

[0002] Gastric motility refers to the peristaltic force of gastric muscle contraction, including the strength and frequency of gastric muscle contraction. Insufficient gastric motility is also "indigestion". Gastric dysmotility is the main cause of non-ulcer dyspepsia. When a person's gastric motility is impaired, symptoms of indigestion such as upper abdominal fullness, easy fullness, abdominal distension after meals, nausea, and vomiting will occur.

[0003] Western medicine believes that the pathogenesis of gastric motility disorder is related to the mechanical motility disorder and disorder of the digestive tract caused by various reasons, and the delay of gastric emptying leads to the decline of gastric motility. Existing gastric motility drug...

Examples

Embodiment 1

[0025] (1) Preparation of fragrant tea extract: add 6 times the amount of 80% ethanol to the fragrant tea and ultrasonically extract 2 times, extract 40min each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 3% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake to extract, concentrate the ethyl acetate layer to dryness, and grind it finely.

[0026] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Fructus and pass through a 10-mesh sieve, add water and reflux for 4 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 3 times the amount of water, filter, pass the decoction through AB-8 macro...

Embodiment 2

[0030] (1) Preparation of Fragrant Tea Extract: Add 5 times the amount of 60% ethanol to the Fragrant Tea and ultrasonically extract 3 times, extracting for 30 minutes each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 5% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake for extraction, concentrate the ethyl acetate layer to dryness, and grind finely.

[0031] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Fructus and pass through a 9-mesh sieve, add water and reflux for 5 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 4 times the amount of water, filter, pass the water decoction ...

Embodiment 3

[0035] (1) Preparation of Fragrant Tea Extract: Add 8 times the amount of 40% ethanol to the Fragrant Tea and ultrasonically extract 3 times, extracting 20 minutes each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 8% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake to extract, concentrate the ethyl acetate layer to dryness, and grind finely.

[0036] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Aurantii and crush through a 12-mesh sieve, add water and reflux for 6 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 3 times the amount of water, filter, pass the decoction through AB-...

technical field

[0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for promoting gastric motility, a preparation method and application thereof. Background technique

[0002] Gastric motility refers to the peristaltic force of gastric muscle contraction, including the strength and frequency of gastric muscle contraction. Insufficient gastric motility is also "indigestion". Gastric dysmotility is the main cause of non-ulcer dyspepsia. When a person's gastric motility is impaired, symptoms of indigestion such as upper abdominal fullness, easy fullness, abdominal distension after meals, nausea, and vomiting will occur.

[0003] Western medicine believes that the pathogenesis of gastric motility disorder is related to the mechanical motility disorder and disorder of the digestive tract caused by various reasons, and the delay of gastric emptying leads to the decline of gastric motility. Existing gastric motility drug...

Examples

Embodiment 1

[0025] (1) Preparation of fragrant tea extract: add 6 times the amount of 80% ethanol to the fragrant tea and ultrasonically extract 2 times, extract 40min each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 3% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake to extract, concentrate the ethyl acetate layer to dryness, and grind it finely.

[0026] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Fructus and pass through a 10-mesh sieve, add water and reflux for 4 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 3 times the amount of water, filter, pass the decoction through AB-8 macro...

Embodiment 2

[0030] (1) Preparation of Fragrant Tea Extract: Add 5 times the amount of 60% ethanol to the Fragrant Tea and ultrasonically extract 3 times, extracting for 30 minutes each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 5% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake for extraction, concentrate the ethyl acetate layer to dryness, and grind finely.

[0031] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Fructus and pass through a 9-mesh sieve, add water and reflux for 5 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 4 times the amount of water, filter, pass the water decoction ...

Embodiment 3

[0035] (1) Preparation of Fragrant Tea Extract: Add 8 times the amount of 40% ethanol to the Fragrant Tea and ultrasonically extract 3 times, extracting 20 minutes each time, add activated carbon to the obtained alcohol extract for decolorization, and the dosage of activated carbon is 8% of the crude drug quality of tea vegetables, centrifuge, concentrate the filtrate to extract, dissolve with ethyl acetate, add saturated sodium carbonate solution and shake to extract, concentrate the ethyl acetate layer to dryness, and grind finely.

[0036] (2) Preparation of Fructus Fructus Citrus Fructus Extract: Take Fructus Fructus Fructus Aurantii and crush through a 12-mesh sieve, add water and reflux for 6 hours, connect the volatile oil extractor and the reflux condenser, and the obtained volatile oil is clathrated with β-cyclodextrin to make β-cyclodextrin Inclusion compound, decoct the remaining medicinal dregs with 3 times the amount of water, filter, pass the decoction through AB-...

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