A method for preparing chitosan/sodium alginate natural polymer core-shell microspheres by one-step method

A technology of sodium alginate and polymer core, which is applied in the field of polymer materials and biomedical materials, can solve the problems of complex polymerization conditions and difficult control of the preparation process, and achieve good repeatability, low production cost and simple preparation steps Effect
CN106582465BInactive Publication Date: 2019-05-24WUHAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN UNIV OF TECH
Publication Date
2019-05-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of polymer materials and bio-medical materials and particularly relates to a method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by a one-step process. The method is characterized by comprising the following steps: firstly, preparing a calcium chloride / chitosan mixed solution and a sodium alginate solution; dripping the calcium chloride / chitosan mixed solution into the sodium alginate solution by use of a microinjector; placing to form microspheres; taking out the microspheres; and cleaning with distilled water to finally obtain the chitosan / sodium alginate natural polymer core-shell microspheres. The method has the advantages that the preparation process is simple, the preparation steps are simplified, the equipment is simple, the preparation conditions are mild, the control is easy, the repeatability is good, after-treatment is not needed, and the cost is low. The natural polymer materials which have the characteristics and advantages of being rich in source, green and environment-friendly, favorable in biocompatibility, non-toxic, biodegradable, and low in price are adopted as the preparation raw material, so that the prepared chitosan / sodium alginate natural polymer core-shell microspheres have a very high application value in the bio-medical field.
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Description

technical field

[0001] The invention belongs to the field of polymer materials and biomedical materials, in particular to a method for preparing chitosan / sodium alginate natural polymer core-shell microspheres by a one-step method. Background technique

[0002] Natural polymer materials are widely used in the field of biomedical materials due to their rich sources, good biocompatibility and biodegradability, and no toxic or side effects. Chitosan is a biological polysaccharide with a wide range of sources, which has excellent properties such as good biocompatibility, biodegradability, and non-toxicity. Moreover, chitosan is a cationic polyelectrolyte amino polysaccharide, and chitosan has a pH-stimulus-responsive dissolution-insolubility transition property: when the pH of the solution is <6.0, the amino group on the chitosan molecular chain can be protonated to make the shell The polysaccharide dissolves, and when the pH of the solution increases (pH>6.0), the amino ...

Claims

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