A kind of synthetic method of carboxylic acid ester compound

A technology of ester compounds and synthetic methods, applied in the preparation of organic compounds, carboxylic acid ester preparation, chemical instruments and methods, etc., can solve the problems of strong acid and strong alkali, unfavorable environmental protection, toxic and harmful heavy metal residues, difficult separation of products and reagents, etc. problems, to achieve good response characteristics, low equipment requirements, and good results
CN106588644BActive Publication Date: 2019-03-29HANGZHOU NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU NORMAL UNIVERSITY
Publication Date
2019-03-29

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Abstract

The invention provides a synthesis method of an ester compound represented by the formula (1), the formula (2) or the formula (3), wherein the method comprises the steps: dissolving an aldehyde compound, sodium azide, tetrabutylammonium iodide and a halogenated compound in a solvent, or directly dissolving an aldehyde compound, sodium azide and tetrabutylammonium iodide in a halogenated compound, carrying out a reaction for 1-12 h at the temperature of 90-100 DEG C, and after the reaction is finished, postprocessing the reaction liquid to obtain the compound represented by the formula (1). The synthesis method has the advantages of mild reaction conditions, no participation of strong acids, strong alkalis or metals, simpliness, high efficiency, high yield, wide application range of substrates, amplified production potential, and relatively large potential economic value.
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Description

(1) Technical field

[0001] The invention relates to a method for synthesizing carboxylate compounds. (2) Background technology

[0002] Carboxylate is an important organic chemical intermediate and pharmaceutical intermediate. In recent research reports, most researchers use noble metals as oxidative esterification catalysts, which are expensive. The traditional synthetic methods of ester compounds focus on the preparation of carboxylic acids and alcohols under strong acid or strong base conditions, but the use of strong acids and strong bases is not conducive to environmental protection and has high requirements for production equipment and great pressure on environmental protection. At the same time, this type of synthetic method is not suitable for the preparation of some special ester compounds sensitive to acid or alkali. Some researchers have used homogeneous catalysts, which have the advantages of high activity and high selectivity in the reaction, but the dosage is ...

Claims

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