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A quantitative method for the determination of parabens in sediments

A technology of parahydroxybenzoic acid and hydroxybenzoate, applied in the field of analytical chemistry, can solve the problems of long analysis time, inconvenience of simultaneous qualitative and quantitative analysis, etc., and achieves the effect of simple steps and shortened measurement time.

Inactive Publication Date: 2019-09-24
HENAN NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem solved by the present invention is to provide a simple, efficient and time-consuming quantitative method for measuring paraben compounds in sediments. It is convenient to realize the shortcomings of simultaneous qualitative and quantitative

Method used

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  • A quantitative method for the determination of parabens in sediments
  • A quantitative method for the determination of parabens in sediments
  • A quantitative method for the determination of parabens in sediments

Examples

Experimental program
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Embodiment

[0021] The instrument used in the experiments in this example was an Agilent 1260 / 6460 liquid chromatography-mass spectrometer.

[0022] 1. Establish and optimize mass spectrometry conditions

[0023] Dilute the single-label stock solution of each target component to 0.2 mg / L on the machine. N 2 As the collision gas, the temperature was 340 °C and the flow rate was 11 L / min; the pressure of the spray needle was 40 Psi; the temperatures of MS1 and MS2 were both set to 100 °C; the scanning mode was multi-ion reaction detection (MRM).

[0024] The selected electrospray ion source (ESI) mode is negative ion mode, the capillary voltage is 3500V, and the corresponding residence time is set according to the sensitivity of each target in the mass spectrometer. The mass spectrometry parameters of formic acid and internal standard are shown in Table 1.

[0025] Table 1 Mass Spectrometry Conditions

[0026]

[0027] 2. Determine the chromatographic conditions

[0028] Column is ...

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Abstract

The invention discloses a quantitative method for testing p-hydroxybenzoate alkyl ester compounds in sediment. The p-hydroxybenzoate alkyl ester compounds comprise methyl parahydroxybenzoat MeP, ethyl p-hydroxybenzoate EtP, propyl p-hydroxybenzoate PrP, butyl p-hydroxybenzoate BuP, n-heptyl 4-hydroxybenzoate HeP and p-hydroxybenzoic acid P-HB, a monostandard of the p-hydroxybenzoate alkyl ester compounds is taken as a quantitative substance, 13C-marked methyl parahydroxybenzoat is taken as an internal standard substance, and an internal standard method is adopted for quantification. The quantitative method disclosed by the invention is relatively simple in whole steps, the testing time of a sample to be tested can be shortened to be 10 minutes, and reference data can be provided for the content of the p-hydroxybenzoate alkyl ester compounds in water body sediment.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a quantitative method for measuring parabens in sediments, in particular to six kinds of parabens and their metabolites, parabens, in water sediments. quantitative method. Background technique [0002] Parabens (Parabens, also known as parabens) are a class of compounds synthesized from parahydroxybenzoic acid and alcohol compounds as the matrix. According to the different connecting groups of alcohol compounds, they can be divided into parabens. Methylparaben, ethylparaben, propylparaben, butylparaben, heptylparaben and benzylparaben and other compounds, the general structural formula is: [0003] [0004] In the formula, R is an organic group, such as Me, Et, etc. [0005] Parabens are known for their excellent spectral antibacterial activity, low toxicity, and inactivity (generally, parabens are stable in air and resistant to hydrolysis in hot, co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 冯精兰赵佳慧席楠楠张飞孙剑辉
Owner HENAN NORMAL UNIV
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