A kind of pharmaceutical composition against fungal infection and its preparation method, preparation and application

Abstract

The invention discloses an anti-fungal-infection pharmaceutical composition and a preparation method thereof, and preparations and application of the pharmaceutical composition. The anti-fungal-infection pharmaceutical composition is prepared from the following raw materials in parts by weight: 20-30 parts of Leucas, 20-30 parts of Senecio scandens, 20-30 parts of kuh-seng, 20-30 parts of phellodendron bark and 10-20 parts of hairy euphorbia. The preparation method comprises the following steps: pretreatment, extraction and after-treatment. The preparations are tablets, capsules, granules, pills and tinctures prepared by adding pharmaceutically acceptable auxiliary materials into the anti-fungal-infection pharmaceutical composition. The application is the application of the anti-fungal-infection pharmaceutical composition in preparation of drugs for preventing / treating fungal infection diseases. The anti-fungal-infection pharmaceutical composition has the function of treating tinea manus and pedis and onychomycosis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for antifungal infection and its preparation method, preparation and application. Background technique [0002] Fungi are a type of eukaryote. The most common fungi are various types of mushrooms, but fungi also include molds and yeasts. More than 70,000 species of fungi have now been discovered, estimated to be only a small half of all that exist. Most fungi were originally classified as animals or plants. [0003] At present, fungi have become independent kingdoms in taxonomy, paralleling the kingdoms of animals, plants, prokaryotes and protists. Fungi have solid cell walls and true nuclei, do not contain chlorophyll, are heterotrophic, live in a parasitic or saprophytic manner, and typically reproduce both sexually and asexually, producing spores of various forms. According to the growth characteristics and morphological difference...

AI Technical Summary

Problems solved by technology

[0004] The classic drug currently on the market for the treatment of fungal infections is griseofulvin, and the drugs for local application are mainly salicylic acid, benzoic acid and other preparations. Since the 1970s, azole antifungal drugs have been mainly used for treatment. The main drugs are clotrimazole, miconazole, econazole and bifonazole, etc., but these antifungal drugs are antifungal drugs, and there is a possibility of relapse after discontinuation. Antibacterial and bactericidal drugs are mainly allylamines, such as naftifine, butenafine, etc., but with the large-scale clinical use, these drugs inevitably have some drug resistance problems. In terms of traditional Chinese medicine treatment, Now clinically, external treatment is mainly used for treatment. Specifically, there are many dosage forms such as tincture, lotion, vinegar, liniment and ointment, and most of them have certain effects, but these medicines are mainly confirmed by preliminary clinical trials. However, strict antibacterial tests in vitro have not been conducted to confirm its exact efficacy, and the onset of therapeutic effect is slow, and the durability of curative effect is poor, so it cannot better meet the needs of patients.

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