Automatic sampler of liquid chromatograph, and automatic correction method of sampling hole of automatic sampler

Abstract

The invention belongs to the technical field of liquid chromatograph equipment, and in particular relates to an automatic sampler of a liquid chromatograph, and an automatic correction method of a sampling hole of the automatic sampler. According to the automatic sampler of the liquid chromatograph, a sealing ring seat mounting groove is formed in a sampling platform; a sealing ring seat is arranged in the sealing ring seat mounting groove; the sealing ring seat is provided with a sealing ring, and the sealing ring is fixed by a sealing ring cover; the sealing ring seat is provided with a sample tube hole; a through hole I is formed in the sealing ring cover, and a through hole II is formed in the sealing ring; a sample tube is arranged in the sample tube hole; the upper end of the sample tube is connected with the sealing ring seat, and the through hole II of the sealing ring is communicated with an inner hole of the sample tube; the sealing ring seat can be translated along the plane direction in the seal ring seat mounting groove, and drives the sealing ring and the sealing ring cover to move synchronously. The automatic sampler can enable a sampling needle to accurately enter the sampling hole and to be well sealed with the sealing ring in the sampling hole, so that the sampling accuracy of the sampler is improved, and the service life of the automatic sampler is greatly prolonged.

Description

technical field [0001] The invention belongs to the technical field of liquid chromatography equipment, in particular to a liquid chromatography automatic sample injector and an automatic correction method for a sample inlet thereof. Background technique [0002] In the liquid chromatograph, the autosampler is a very important unit, which is used to reduce the use of manpower during the operation of the instrument, so that the instrument can automatically sample, inject and analyze without being on duty. Part of the work that requires skilled operators. [0003] Traditional autosamplers require a needle to draw the liquid from the reagent bottle and inject it into the corresponding injection valve, and then enter the separation system through the injection valve. [0004] In the early injectors, the sample was drawn by the injection needle and entered into the quantitative loop of the injection valve. During the injection, the sample was washed out of the quantitative loop ...

AI Technical Summary

Problems solved by technology

[0009] When the sample enters the system, the pressure of the mobile phase in the system is higher than the atmospheric pressure. For ultra-high performance chromatography, the maximum pressure can even reach more than 100Mpa. Therefore, the injection needle and the sealing ring must have good sealing performance. If the sealing performance is not good enough , it will cause system pressure loss or leakage

[0010] If the injection needle does not enter the sealing ring accurately, it will also lead to a decrease in the tightness of the system

What's more serious is that the sampling needle has a certain hardness, and the sealing ring is usually made of corrosion-resistant elastic resin. The position deviation of the sampling needle can easily damage the outer shape of the sealing ring and cause wear on the internal sealing part, affecting the sealing. cycle life; in addition, it may also cause a large amount of sample residue to be left in the injection port, resulting in the occurrence of sample residue contamination of the next sample injection.

Finally, since the external environment is atmospheric pressure, the system is usually in a high pressure state, and the pressure difference is large, so when the leakage is serious, liquid jets will be generated, which will also cause damage to the hardware of the instrument itself

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